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Princical Investigator/Program Director (Last, first, middle): _ 
BIOGRAPHICAL SKETCH 
Give the following information for the key personnel and consultants and collaborators. Begin with the principal 
investigator/program director. Photocopy this page for each person. 
POSITION TITLE 
Associate Professor of Medicine 
EDUCATION (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) 
INSTITUTION AND LOCATION 
DEGREE 
YEAR 
CONFERRED 
FIELD OF STUDY 
University of North Carolina, Chapel Hill, NC 
A.B 
1967 
Chemistry 
University of North Carolina, Chapel Hill, NC 
M.D. 
1971 
Medicine 
Ohio State University, Columbus, OH 
Int. Med 
1973 
Medicine 
Duke University, Durham, NC 
Resident 
1975 
Medicine 
University of North Carolina, Chapel Hill, NC 
Fellow 
1980 
Pulmonary Medicine 
RESEARCH AND PROFESSIONAL EXPERIENCE: Concluding with present position, list, in chronological order, previous employment, experience, and 
honors. Key personnel include the principal investigator and any other individuals who participate in the scientific development or execution of the project. 
Key personnel typically will include all individuals with doctoral or other professional degrees, but in some projects will include individuals at the masters or 
baccalaureate level provided they contribute in a substantive way to the scientific development or execution of the project. Include present membership on 
any Federal Government public advisory committee. List, in chronological order, the titles, all authors, and complete references to all publications during the 
past three years and to representative earlier publications pertinent to this application. DO NOT EXCEED TWO PAGES. 
Employment History: 
1975-1978 Chief, Internal Medicine, U.S. Air Force, Malcolm Grow Medical Center, Andrews 
AFB, Washington, DC 
Instructor, Department of Medicine, University of North Carolina-Chapel Hill 
Assistant Professor, Medicine, Department of Medicine, UNC-Chapel Hill 
Associate Professor, Medicine, Department of Medicine, UNC-Chapel Hill 
1980-1982 
1982-1987 
1987-Present 
Awards and Special Appointments: 
Morehead Scholar, University of North Carolina, 1963-1967 
Instructor, Medicine, Uniformed Services University of Health Sciences, Bethesda, MD, 1977-78 
Jefferson Pilot Fellowship in Academic Medicine, UNCarolina-Chapel Hill, 1983-87 
Research Sabbatical: Laboratory of Molecular Neurobiology, Medical Research Council and 
Department of Pharmacology, Cambridge University, England, 1988-89 
Visiting Clinical Scholar,, Heart-Lung Transplantation Unit, Papworth Hospital, Cambridge, 1988-89 
Publications: (20 of 83) 
1. Knowles, M.R., P. Gilligan, and R.C. Boucher. Cystic fibrosis. In: Principles and Practice of 
Infectious Diseases . G.L Mandell, R.G. Douglas, Jr., and J.E. Bennett, editors. 3rd ed. Churchill 
Livingstone, Inc., New York, pp 579-589, 1989. 
2 Boucher, R.C., E.H.C. Cheng, M.J. Stutts, M.R. Knowles, and H.S. Earp. The chloride secretory 
response of cystic fibrosis (CF) human airway epithelia: Preservation of calcium ionophore but not 
protein kinase C and A-Dependent mechanisms./. Clin. Invest. 84.1424-1431, 1989. 
3 Knowles, M.R., T.B. Barnett, A. McConkie, C. Sawyer, and S.G. Kahler. Mild cystic fibrosis in a 
consanguineous family: Clinical aspects. Ann. Intern. Med. 110:599-605, 1989. 
4. McConkie-Rosell, A,, Y.T. Chen, M.R. Knowles, L. Silverman, D. Harris, M.C. Speer, M.A. 
Pericak- Vance, J.H. Ding, and S.G. Kahler. Mild cystic fibrosis linked to chromosome 7q22 markers 
with an uncommon haplotype. Ann. Intern. Med. 11 1.797-801, 1989. 
5 Orlando RC DW Powell, R.D. Croom, H.M. Berschneider, R.C Boucher and M.R. Knowles. 
Colonic and esophageal transepithelial potential difference in cystic fibrosis. Gastroenterology 
96:1041-1048, 1989. 
PHS 398 (Rev. 9/91 ) ( Form Pa ? e 6 > Page 
Number SUf, ' XeS $UCh 35 33 ' 3b ' 
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