Principal Investigator/Program Director (Last, first, middle): Seigler, Hilliard F. 
BIOGRAPHICAL SKETCH 
Give the following information for the key personnel and consultants and collaborators. Begin with the principal 
investigator/program director. Photocopy this page for each person. 
NAME POSITION TITLE ~ 
Hilliard F. Seigler, M.D. Professor of Surgery, Professor of Immunology 
EDUCATION (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) 
INSTITUTION AND LOCATION 
DEGREE 
YEAR 
CONFERRED 
FIELD OF STUDY 
University of North Carolina-Chapel Hill, 
NC 
B. A. 
1956 
Chemistry 
University of North Carolina-Chapel Hill, 
NC 
M.D. 
1960 
Medicine 
Duke University-Durham, NC (Post-Doctoral 
fpl 1 nv) ' 
Immunogenetics 
RESEARCH AND PROFESSIONAL EXPERIENCE: Concluding with present position, list, in chronological order, previous employment, experience, and 
honors. Key personnel include the principal investigator and any other individuals who participate in the scientific development or execution of the project. 
Key personnel typically will include all individuals with doctoral or other professional degrees, but in some projects will include individuals at the masters or 
baccalaureate level provided they contribute in a substantive way to the scientific development or execution of the project Include present membership on 
any Federal Government public advisory committee. List in chronological order, the titles, all authors, and complete references to all publications during the 
past three years and to representative earlier publications pertinent to this application. DO NOT EXCEED TWO PAGES. 
PROFESSIONAL EXPERIENCE: 
1983-present 
1981-present 
1981-present 
1977-present 
1971-1977 
1971-1972 
1967-1970 
1965-1967 • 
1964-1965 
PUBLICATIONS: 
Present Editorial Board, Annals of Surgery 
Professor of Immunology, Duke University Medical 
Center, Durham, N.C. 
Research Professor, Yerkes Regional Primate Center, 
Emory University, Atlanta, GA 
Professor of Surgery, Duke University Medical 
Center, Durham, N.C. 
Associate Professor of Immunology, Duke University 
Medical Center, Durham, N.C. 
Chief of Surgery, Veterans Administration Hospital, 
Durham , N.C. 
Assistant Professor of Surgery, Duke University 
Medical Center, Durham, N.C., Clinical 
Investigator, Veterans Administration Hospital, 
Durham, N.C. 
Research Fellow of Immunogenetics, NIH Special 
Fellowship, Duke University medical Center, Durham, 
N.C. 
Chief Resident in Surgery, University of North 
Carolina, Chapel Hill, N.C. 
From 240 publications 
Crowley, N.J., Darrow, T.L. , and Seigler, H.F.: Generation of 
Autologous Melanoma-Specific Cytotoxic T-cells using HA-A2 
Region Matches Allogeneic Melanomas. Cancer Research 50: 492- 
498, February 1, 1990. 
Darrow, T.L., Quinn-Alien, M.A. , Crowley, N. J. , and Seigler, H.F.: 
Modulation of In Vitro Autologous Melanoma Specific Cytotoxic 
T-cells Responses by Phorbol Dibutyrate and Ionomycin. 
Cellular Immunology 125, 508-517, 1990. 
Crowley, N.J., Slingluff, C.L., Darrow, T.L., Vervaert, C.E., and 
Seigler, H.F.: Inhibition of the Growth of Human Melanoma 
Xenografts in Nude Mice by Human Tumor-Specif i ~ t- 
[654] 
Recombinant DNA Research, Volume 17 
