LEGEND FOR FIGURE 1 
Mice were given chemotherapy following hematopoietic recovery (this 
requires 2-3 weeks). The chemotherapy was Taxol, freshly 
reconstituted at 7 , 10, 14, 20, and 30 mg/kg. 
The time course of recovery from Taxol-induced myelosuppression was 
measured following two or three doses of chemotherapy. The data from 
these experiments is shown in Figure 1 in which the following 
experimental groups are outlined: 
Marrow containing Gottesman virus following: 
Curve 1: Two courses of 10 mg/kg Taxol; 
Curve 2: Three courses of 7 mg/kg Taxol; 
Curve 3: Three courses of 14 mg/kg Taxol; 
Marrow containing our laboratory virus following: 
Curve 4: Three courses of 14 mg/kg Taxol; 
Curve 5: Three courses of 7 mg/kg Taxol; 
Curve 6: Two courses of 10 mg/kg Taxol; 
Marrow containing no virus following: 
Curve 7: One course of 10 mg/kg Taxol; 
Curve 8: One course of 14 mg/kg Taxol; 
Curve 9: One course of 20 mg/kg Taxol; 
Curve 10: One course of 30 mg/kg Taxol; 
The mice died following 20 and 30 mg/kg without virus. 
This data shows a faster recovery and a reduction in the degree of 
myelosuppression following virus when given our laboratory virus and 
two or three courses of Taxol at 10 and 14 mg/kg. The degree of 
protection given by the Gottesman virus was similar to that observed 
with our own laboratory virus. 
Recombinant DNA Research, Volume 17 
[6671 
