Non-Technical Abstract 
17.0 Non-technical Abstract 
Many types of cancer cannot be cured by traditional medical 
treatments, including drugs, surgery, or radiation. In this 
study, an experimental treatment will be offered that may help to 
fight this disease. We will attempt to induce tumor regression 
by the introduction of genetic material that directs the 
synthesis of proteins which stimulate the immune system. The 
genetic material, DNA, will be introduced directly into the tumor 
by mixing it with fat bodies, or liposomes, and this mixture will 
be injected into the tumor or delivered by a catheter. The DNA 
will be taken into cells and cause them to produce proteins that 
stimulates tissue rejection. These proteins, called 
histocompatibility proteins, cause cells which contain it to be 
recognized as foreign by the immune system. In some cases, 
another immune stimulatory protein, interleukin, will also be 
included. The goal of the treatment is to stimulate the immune 
system to attack and kill the tumor. In this study, we will 
determine a safe and effective dose to administer the DNA 
liposome complex. Increasing amounts of this complex will be 
used in different patient populations. If no side effects are 
observed, repeated treatments will be instituted. The expression 
and nature of the immune response will also be characterized. 
This treatment may provide a therapeutic effect in cancer and 
could be applied to the treatment of other diseases. 
Recombinant DNA Research, Volume 17 
[689] 
