GTI0101 (04/08/93) 
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SCHEMATIC 
Bone Marrow Harvest - 1 Cycle only 
Patients with Gaucher Disease 
Harvest Bone Marrow Cells 
Filter and process to recover CD34-enriched Cells 
(Day 1) 
Discharge patient from hospital if clinically indicated 
(Day 2) 
Transduce CD34+ cells with GC-gene containing retroviral vector 
(Days 1-3) 
Transduced cells reinfused into patient 
(Day 4) 
Patient Discharged 
(Day 5) 
Patient Follow-up 
Recombinant DNA Research, Volume 17 
[791] 
