POTENTIAL BENEFITS 
There are no direct benefits to you from participating in 
this study. It is possible that the results of the study will 
lead to a new therapy ("gene therapy") which may benefit you in 
the future. 
STUDY PLAN 
The first part of the study plan involves removing a portion 
of your bone marrow. You will be brought to the operating room 
and be placed under general anaesthesia. The doctors will then 
remove about 2 cupfuls of bone marrow from the area on the back 
of your hip bone known as the posterior iliac crest. The removal 
is done with needles that are placed through the skin and then 
through the outer surface of the bone. The removal of bone 
marrow takes one-two hours and will require an overnight hospital 
stay. 
We will then treat your bone marrow cells in the laboratory 
for 3-4 days with a virus, which was engineered to carry the 
normal GC gene into bone marrow cells. Once the GC gene is in 
the cells, it is permanent, and the cell will pass the GC gene on 
to all of its daughter cells. The mouse virus has been altered 
so it cannot grow or spread in your body. 
The next part of this experiment will involve putting your 
treated bone marrow cells back into your body. The cells will be 
put into your body through an intravenous line. The infusion 
will take place on the Bone Marrow Transplant Unit and will take 
four to six hours. You will be monitored closely for side 
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