hospital stays, associated with this study. You will continue to 
be responsible for the costs of standard care, including enzyme 
replacement . 
ALTERNATIVE TREATMENTS 
Participation in this study is completely voluntary and is 
not intended to be therapeutic. The alternative would be for you 
not to participate in the study. 
POTENTIAL RISKS 
The principal risk of the marrow removal is associated with 
the administration of general anesthesia. General anesthesia can 
cause problems, such as allergic reactions, breathing or heart 
problems including the possibility of death. Other risks include 
bleeding, pain, or infection at the bone marrow aspiration sites. 
You will receive pain medication to relieve pain if necessary. 
There is a small possibility that the bone marrow harvest will 
make you anemic enough to require a blood transfusion. 
The laboratory procedures used to treat your bone marrow are 
experimental, but have been safely used in over 50 patients 
without any known side effects. There are no known risks in 
receiving bone marrow cells that contain the new GC gene 
introduced by the virus. At the time the marrow cells are 
infused back into your bloodstream, you may experience fever, 
chills, difficulty breathing, and rarely, a severe allergic 
reaction that can lead to death. You will be treated for an 
allergic reaction, if it occurs. 
Recombinant DNA Research, Volume 17 
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