APPENDIX C 
DEPARTMENT OF HEALTH, EDUCATION, AND WELFAR 
PUBLIC HEALTH SERVICE 
NATIONAL INSTITUTES OF HEALTH 
Director, NIH 
Through: Director, NIGMS, NIH 
June 18, 1976 
FROM : Executive Secretary 
Recombinant DNA Molecule Program Advisory Committee 
SUBJECT: Operation of the Office of Recombinant DNA Activities (ORDA) 
The proposed structure and responsibilities of an Office of Recombinant 
DNA Activities (ORDA) were described in Dr. Kirschstein' s memorandum, 
to you of April 28, 1976. The purpose of this document is to present 
our views as to hov/ such an office can function effectively at the NIH. 
Consequently, the following relationships and activities are discussed: 
I. Office of the Director, NIH (OD,NIH) 
The Office of Recombinant ENA Activities (ORDA) will be respon- 
sible for keeping the Office of the Director, NIH, (OD,NIK) and 
particularly the Deputy Director for Science informed concerning 
the activities of ORDA, the status of BID extramural programs 
and intramural research involving recombinant ENA molecules, and 
on scientific and public developments which may affect NIH policy 
decisions and procedures regarding recombinant DNA technology. 
ORDA will interact with the Deputy Director for Science and the 
Associate Director for Collaborative Research, NIH in their 
capacities as chairman and vice-chairman, respectively, of the Re- 
combinant DNA Molecule Program Advisory Committee (Recombinant 
Advisory Committee) . 
OD, NIH, in turn, should involve ORDA in all major plcinning activi- 
ties leading to formulation of NIH policies and procedures. As 
is current practice, the Executive Secretariat, NIH will provide 
ORDA with information copies of all correspondence relating to 
recombinant ENA matters. OD, NIH should provide ORDA with copies 
of outgoing correspondence, responses to Congressional inquiries, 
etc., to ensure that the NIH maintains uniform positions on the 
various matters relating to this technology. 
An Executive Recombinant ENA Committee (Executive Committee) 
should be established in the Office of the Director, NIH. Members 
of the Committee would be: Deputy Director for Science (Chairman); 
Associate Director for Extramural Research and Training; Associate 
Director for Collaborative Research; Associate Director for Program 
Planning and Evaluation; Director, Office of Research Safety, NCI; 
Appendix C — 1 
