APPENDIX C 
and Associate Director for Environmental Health and Safety, 
DRS. The Special Assistant for Intramural Affairs will serve 
as Executive Secretary of the Executive Committee. There will 
be representation on this committee of one or more of the BIDs 
most involved in the support of research utilizing this tech- 
nology. Problems (such as suitability of institutional biohazards 
committees, adequacy of review of applications, appropriateness 
of proposed new initiatives by BIDs, etc.) v^ich cannot be 
resolved at the level of ORDA will be referred to the Executive 
Comjnittee. Problems which can not be resolved at the level of 
the Executive Committee will be referred to the Recombinant 
Advisory Committee or subcommittees thereof by telephone, mail 
or presentation at the next meeting. The Deputy Director for 
Science will have the ultimate responsibility for decisions 
and can make urgent decisions without consultation with the 
committees. (OD,NIH may wish to propose an alternative approach 
other than the establishment of an Executive Committee). 
The Deputy Director for Science, NIH, will have the responsibility 
for assigning to the individual BIDs various projects developed 
by the Executive Committee or Recombinant Advisory Committee or 
solicited by ORDA. 
The Office of the Director, NIH will be responsible for promul- 
gation and enforcement of regulations, and for accountability 
to congressional committees, DHEW, and the public. ORDA will 
keep the Deputy Director for Science, NIH informed of any poten- 
tial problems which may lead to regulatory activities and/or 
need for accountability and may make appropriate recommendations 
in these circumstances. 
Dissemination of Information 
The Office of the Director, NIH will be responsible for the 
promulgation of Guidelines for Research Involving Recombinant 
DNA Molecules (Guidelines), and should undertake the initial 
mass distribution of Guidelines to institutions and research 
laboratories through its mailing keys and use of the appropriate 
instrument, such as the NIH Guide for Grants and Contracts (NIH 
Guide), NIH Manual Issuance (NIH Manual), etc. Thereafter, ORDA 
will be responsible for distributing Guidelines and responding 
to requests by institutions and investigators regarding NIH 
policies and procedures. Dissemination of major changes in the 
Guidelines should also be handled as above. 
The NIAID will have responsibility for publication of the Nucleic 
Acid Recombinant Scientific Memoranda (NARSM) . Major announcements 
in NARSM, such as distribution of Guidelines, statements of NIH 
Appendix C — 2 
