APPENDIX A TO APPENDIX C 
Processing, Review, and Management of Extramural Projects 
Involving Recoinbinant DNA Technology 
I. General 
The purpose of this appendix is to discuss procedures for the 
processing, review and management of NIH supported projects 
which involve the use of recombinant IX-JA technology. The term 
"application", as used here, refers to all contract proposals 
and grant applications for research projects, program projects, 
centers, training, fellowships, research career develonaent , 
etc., as defined in NIH Manual Issuance 4101: Activity Codes , 
Organizational Codes and Definitions used in Extramural Programs 
The procedures would apply to applications reviev/ed by DRG study 
sections and Institute and Division initial review groups. 
II. Capture of Information 
One of the primary functions of the Office of Recombinant DNA 
Activities (ORDA) is to maintain a central register of NIH 
supported projects which involve recombinant DNA technology 
so that the NIH will know where these projects are located 
and will have the capability of rapidly communicating with 
project directors should the need arise. 
In order to maintain an updated central register of projects 
it will be necessary for the NIH to modify application forms 
to indicate on the face sheet whether or not recombinant DNA 
technology is involved in the project. This could be modeled 
after the statement currently in use regarding research in- 
volving . hum.an subjects. This information would be captured, 
as is the case for human experimentation, and permit sorting 
by different parameters such as awarding component, geographic 
location of projects, etc. 
III. Receipt of Applications 
Through the use of the appropriate instrument (NIH Guide, NIH 
Manual, etc.), the NIH will inform applicants of th^ necessity 
for assessing the physical and biological containment required 
for the proposed experiments as stipulated in the NIH guidelines 
This assessment must be incorporated into the application. 
All applications requesting support for projects involving re- 
combinant CWA jtechnology will be required to have on file two 
documents: a Memorandum of Understanding and Agreement (MUA) , 
Appendix C — 7 
