APPENDIX A TO APPENDIX C 
established f will make a decision independently. The decision 
v/ill be forwarded to the program official who may appeal. The 
final decision rests with the Deputy Director for Science, NIH. 
Large-Scale Experiments 
The Guidelines state that: 
at this time large-scale experiments (e.g., 
more than 10 liters of culture) with recombinant 
DNAs knov.n to make harmful products are not to be 
carried out .... However, specific experiments 
in this category may be exempted from this rule if 
special biological containment precautions and equip- 
ment designed for large-scale operations are used, 
and provided that these experiments are expressly 
approved by the Recombinant TOA Molecule Program 
Advisory Committee. 
An investigator who wishes to conduct such experiments must sub- 
mit a request, along with a properly executed MUA and Certification 
Statement from the institutional biohazards committee, to the pro- 
gram official of the NIH awarding component. The program official 
will retain the original request in the awarding component's file, 
and forward copies to ORDA. ORDA v;ill bring the request to the 
attention of the Recombinant Advisory Committee or subcommittees 
thereof, by mail, telephone, or presentation at the next meeting or, 
if a precedent has been established, will make a decision 
independently . 
Appendix C — 12 
