M fc N 7- 
APPENDIX D TO APPENDIX C 
DEPARTMENT OF HEALTH. EDUCATION, AND WELFARE 
PUBLIC HEALTH SERVICE 
NATIONAL INSTITUTES OF HEALTH 
BETHESDA, MARYLAND 20014 
August 26, 1976 
MEMORANDUM 
To: 
NIH Grantee Institutions and Contractors 
From 
Director, NIH 
Subject: Conduct of Experiments Involving Recombinant DNA Molecules 
On June 23 the National Institutes of Health (NIH) issued Guidelines 
for Research Involving Recombinant DNA Molecules. The NIH released 
these guidelines after extensive scientific and public airing of the 
issues during the sixteen months which have elapsed since the Inter- 
national Conference on Recombinant DNA Molecules in February 1975. 
The chronology leading to the present guidelines is described in detail 
in the NIH Director's decision document which is published with the 
guidelines in the Federal Register for July 7, 1976. 
These guidelines replace the recommendations contained in the 1975 
Summary Statement of the Asilomar Conference on Recombinant DNA 
Molecules. It is imperative that NIH grantee institutions and con- 
tractors take immediate steps to ensure that research projects 
involving recombinant DI'IA molecules are conducted in coinpliance with 
the guidelines. Procedures which your institution must implement are 
described in the accompanying memorandum from the NIH's Office of 
Recombinant ESIA Activities. 
The careful and thorough implementation of the guidelines by the NIH 
and its grantees and contractors is essential to their effectiveness. 
This is a matter of highest priority, and I urge you to give it your 
immediate attention. 
Donald S. Fredrickson, M.D 
Enclosure 
Appendix C — 19 
