APPENDIX D— 40 
In CASE OF 0AM AGf 
OR leakage 
NOTIf V OIAECTOR COC 
' ATLANTA. CCORGtA 
404/6)3 53T3 
(i) The color of material on which the label 
is printed must be white and the symbol and 
printing in red. 
(il) The label must be a rectangle meas- 
uring 51 mm. (2 inches) high by 102.5 mm. 
(4 inches) long. 
(Hi) The red symbol measuring 38 mm. 
(I 1/2 Inches) in diameter must be centered 
in a white square measuring 51 mm. (2 
Inches) on each side. 
(iv) Type size of the letters of label shall 
be as follows; 
ETIOLOGIC AGENT 10 pt, rev, 
BIOMEDICAL MATERIAL 14 pt. 
IN CASE OF DAMAGE OR 
LEAKAGE 10 pt. rev. 
NOTIFY DIRECTOR CDC AT- 
LANTA. GA 8 pt. rev. 
404 633 5313 10 pt. rev. 
(5) Damaged packages. Carriers shall 
promptly, upon discovery of damage to the 
package that indicates damage to the pri- 
mary container, isolate the package and no- 
tify the Director, Center for Disease Control. 
1600 Clifton Road NE., Atlanta. GA 30333 
(telephone (404) 633-5313), and the sender. 
(6) Registered mail or equivalent system. 
Transportation of the following etiologic 
agents shall be by registered mail or an 
equivalent system which requires or provides 
for sending notification to the shipper imme- 
diately upon delivery: 
Actinobacillus mallet. 
Coccidioides immitis. 
Francisella (Pasteurella) tularensis. 
Hemorrhagic fever agents, including, but not 
limited to, Crimean hemorrhagic fever 
(Congo ) , Junin, Machupo viruses. 
Herpesvirus simiae (B virus). 
Histoplasma capsulatum. 
Lassia virus. 
Marburg virus. 
Pseudomonas pseudomallei. 
Tick-borne encephalitis virus complex. In- 
cluding, but not limited to, Russian spring- 
summer encephalitis, Kyasanur forest dis- 
ease, Omsk hemorrhagic fever, and Central 
European encephalitis viruses. Variola 
minor and Variola major. 
Yersenia (Pasteurella) pestis. 
(d) Notice of delivery; failure to receive. 
When notice of delivery of agents containing, 
or suspected of containing, etiologic agents 
listed In paragraph (c) (6) of this section Is 
not, received by the sender within 5 days fol- 
lowing anticipated delivery of the package, 
the shipper shall notify the Director, Center 
for Disease Control, 1600 Clifton Road NE.. 
Atlanta. GA 30333 (telephone (404) 633- 
6313). 
(e) Requirements; variations. The Ad- 
ministrator may approve variations from 
the requirements of this section if, upon re- 
I view and evaluation, he finds that such varia- 
I tlons provide protection at least equivalent 
to that provided by compliance with the re- 
quirements specified In this section and 
makes such findings a matter pf official 
1 record. 
I (Sec. 361, 58 Stat. 703; 42 U.S.C. 264) 
I (PR Doc.72-9887 Plied 6-29-72:8:45 am) 
Effective July 30, 1972 
PACKAGING AND 
LABELING OF 
ETIOLOGIC 
AGENTS 
FIGURE 2 
Th? Inicrit.iic OiLi'uiiIiiie Regiiljiifjnj !42 CFH, P.iil 72 2D 
Etiologic Agents! was revised July 31. 1972 to |miYi:lti Iff 
p.ickngiog iind labeling requirements fur iMioloijic .ujents tiul 
certain other materials shipiKxt in interstate tr.ilfic. 
Figures 1 and 7 dingram the pAckogmg iiiu! (abelnuj uf etiu 
logic agents in volumes of less than 50 ml. in accordunce with 
the provisions of subparagraph (C| (1) of thr: cited regdlatioii. 
Figure 3 illustrates the color and size of tlie Ul>el, described 
in subparagraph (C) (4) of the regubitiuns, which shiilt be 
affixed to all shipments of etiologic agents. 
For fufth.'' iiifornol -.n on any provision of lliii fcijuliilioil 
co'U.ict; 
Center for Disease Control 
Attn: Biohazards Coiitrut OMice 
1600 Chfion Road 
Atlanta. Geoiyu 30333 
Ti-lc-phime; 404 033 33 M 
Figure 3 
ETIOLOGIC AGENTS 
llOMEDICAL 
MATiRIAL 
IN CASE OE DAMAGE 
OR leakage 
404/633.5313 
PACKAGING AND LABELING OF ETIOLOGIC AGENTS 
ABSORBENT PACKING MATERIAL 
PRIMARY CONTAINER (Bottle, hhod huj. etc.l’ 
•NOTE; Single primary conlalncrs may not exceed 500 
ml. of material. Two or more primary containers whoye 
combined volumes do not exceed 500 ml. may be en- 
closed in a single, secondary container. The maximum 
volume of etiologic agent which may be enclosed In a 
single outer shipping container shall not exceed 4000 ml.. 
SHOCK ABSORBENT MATERIAL 
SECONDARY CONTAINER (Cmketed screwccp 
with waterproof tape or hermetically seated can) 
OUTER SHIPPING CONTAINER 
MAILING LABEL 
ETIOLOGIC AGENT LABEL 
The Interstate Quarantine Regulations (42 CFR, Pan 
72.25, Etiologic^ Agents) was revised |uly 3t, 1972, W 
provide for packaging and labeling requirements for eti» 
logic agents and certain other materials shipped in inter- 
state traffic. The illustration shows acceptable packaging 
and labeling of etiologic agents in accordance with sub- 
paragraphs (c) (2) and (4) of the cited regulation. 
For further information on any provision of this regulation contact: 
Center for Disease Control 
Attn: Biohaiardt Control Office 
1600 Clifton Road 
Atlanta, Georgia 30331 
Telephone 404.633 3311 
