APPENDIX E 
extend the requirements in the guidelines to research supported by private 
funds. In the meanwhile it is anticipated that voluntary compliance by the 
private sector will be extensive. 
4/ 
Guidelines in other countries . The United Kingdom has independently 
developed guidelines for research with recombinant DMA. Comparison of the 
American and British guidelines suggests that they are similar, although 
precise comparison is difficult because of different definitions of physical 
containment categories and because of differing approaches to implementation, 
required by differing national procedures. The British document has somewhat 
more stringent definitions than the NIH guidelines for the lower levels 
of physical containment (PI through P3): the NIH P4 specifications appear 
to be more stringent than the comparable level in the British document. 
No experiments are specifically prohibited by the British Report. 
More precise comparison will be possible as specific experiences accumu- 
5/ 
I ate . 
Appendix E — 23 
