Dr. Donald Fredrickson 
October 12, 1976 
Page 10 
6. Donald Fredrickson, "Decision of the Director, National 
Institutes of Health, to Release Guidelines for Research 
on Recombinant DNA Molecules," Federal Register, Vol. 41, 
No. 131, July 7, 1976, p. 27904, col. 1. Referred to in the 
following as "Decision." 
7. EIS, p. 6. 
8. Fredrickson, "Decision," pp. 27906-27910. See also Donald 
Fredrickson, Letter to Science 193 (September 24, 1976), 
p. 1192. 
9. Position Paper, Document 1, parts 2-4; Document 2. 
10. Ibid., Document 1, part 4. 
11. EIS, p. 64. 
12. Fredrickson, "Decision," p. 27904, col. 2. 
13. Paul Berg to Donald Fredrickson, February 17, 1976, and testi- 
mony to The University of Michigan Board of Regents, May 12, 
1976. 
14. British Health and Safety Commission, "Compulsory Notification 
of Proposed Experiments in the Genetic Manipulation of Micro- 
organisms," (Consultative document), August 25, 1976. 
15. This proposal is more restrictive than that considered in 
the EIS, VI. C. 3, since the latter might foster a prolifera- 
tion of P4 facilities. 
16. Document 1. 
17. There might be some minor exceptions to this generalization, 
namely, experiments using DNA from prokaryotes which are 
known to exchange genetic information with E.coli and when 
the DNA contains no pathogenic properties. It should be noted 
that a decision on this matter contains an important policy 
element: it would determine the number of students trained 
in a hazardous technique. 
18. EIS, p. 51. 
19. Federal Register, Vol. 39, No. 215, November 6, 1974, p. 39306. 
20. EIS, p. 2. See also Donald Fredrickson, Letter to Science 
193 (September 24, 1976), p. 1192. 
21. Erwin Chargaff, Letter to Science 192 (June 4, 1976) , p. 938 
(Position Paper, Document 4); Robert Sinsheimer to Donald 
Fredrickson, February 5, 1976 (position Paper, Document 7). 
Appendix K — 39 
