SPONSOR RESPONDENTS 
1, Hudson Hoagland agreed with all the points mentioned and called them "very well 
summarized" and congratulated the author on them. 
Dr. Hoagland is one of FAS's oldest Sponsors, a physiologist, the co-founder 
of the Worcester Foundation for Experimental Biology, later its Director, Presi- 
dent and now its President Emeritus. Among his awards are the Humanist of the 
Year Award, and the Modern Medicine Award. 
2. Arthur Kornberg disagreed with all the points mentioned and felt that the position 
they represented would "seriously impede research in nucleic acids, biology and 
medicine. It will hamper the spirit of open and free inquiry of science in gen- 
eral." He felt that the issue was "enormously overblown" and that recombinant DNA 
would not make the "top 20 or even the top 100" existing and potential hazards. 
Dr. Kornberg received the Nobel Prize in Medicine in 1959, was for ten years 
the Chairman of the Department of Biochemistry at Stanford University, and is the 
holder of numerous awards for his work in this field. 
3. Christian Anf insen agreed with all the points mentioned except point V (Impact 
Statement Should be More Explicit About Containment Costs). He noted that "The 
draft statement, as is, is an excellent and thorough labor of love." 
Dr. Anf insen received the Nobel Prize in Chemistry in 1972 and is the Chief 
of the Laboratory in chemical biology at the National Institute for Arthritis and 
Metabolic Diseases in NIH. 
4. Matthew Meselson found it difficult to respond to the specific points because, 
he felt, they appear to be charged with a fundamental misconception that there 
is reason to perceive danger in recombinant DNA. In fact, the guidelines are 
very responsible and the experiments are intrinsically without demonstrable danger. 
This is the greatest safeguard of all. To superimpose biological and physical 
constraint adds an even higher degree of protection. As a result, for all practi- 
cal purposes of decision-making, the risk of recombinant DNA is negligible. 
Professor Meselson is the Chairman of the Department of Biochemistry at 
Harvard University and received in 1972, the FAS Annual Public Service Award for 
his work against biological warfare and in support of the Geneva Protocol. 
5. Two other Sponsors responded less directly. Dr. David Baltimore felt that the obser- 
vations in the memorandum would complicate rather than assist the present situation. 
Dr. George Wald was sympathetic to them. Both of these Sponsors have Nobel prizes 
in their fields and both are active in discussing the problem of recombinant DNA. 
Appendix K — 48 
