3 
(1) That the Recombinant DN'A Molecule Proyram Advisory 
Committee, which drafted the Guidelines, and the authors of the 
impact statement have accurately imagined or anticipated all 
possible kinds of potential hazardous situations resulting from 
recombinant DNA research or technology. While there is clearly 
insufficient data to accurately estimate the probability of 
occurrence of any untoward event, it is essential that the nature 
of the organisms or virus v;ith a potential for environmental 
harm or disease be understood, in order that appropriate safety 
and containment procedures may be designed. 
(2) All parties engaged in recombinant DNA research or 
technology will respect the NIH Guidelines and will comply with 
the safety precautions outlined therein, whether or not they 
are bound by law or regulation to do so. 
(3) The safety procedures outlined in the Guidelines, 
including the use of biological containment, will always be 
faithfully executed. That is, it is assumed that there will be 
no serious human errors committed, equipment failvires or accidents 
which would negate their presumed effectiveness. 
I would dispute the validity of each of the above assumptions 
It is, at best, naive and idealistic to assume that we are wise 
enough to be able to imagine all of the manifestations of the 
infinite variety of possible genetic chimeras, when we don't 
even understand much of the genetic function in existing organisms 
At worst, it is preumptuous and arrogant. In no case, can it be 
justified. And it is equally naive and idealistic to assume that 
Appendix K — 57 
