to produce a bacteria which could produce insulin inexpensively 
(Janice Crossland, "Hands on the Code, " Environment 18:6 (September 
1976) . NIH should also consult with international organizations 
to determine which recombinant DNA activities conducted by 
foreign countries may be subject to regulation by the United 
States . 
D • The Adverse Environmental Impacts of Promulgating 
The Guidelines Are Not Adequately Described 
(Section VII, Draft EIS) 
1. The Impact of Uncontrolled Recombinant DNA 
Activities 
The impact of experiments which are not governed 
by the Guidelines are not discussed at all. Because these 
experiments are not subject to any safety procedures or prohi- 
bitions against especially dangerous experiments, they pose 
a much greater risk to the public health and environment than 
NIH supported research. It is very likely that some of these 
uncontrolled experiments will result in the intentional or 
accidental release of organisms with recombinant DNA molecules 
into the environment. If those organisms survive and multiply, 
they could cause spreading and unstoppable disease or damage to 
the environment. Even one release of such organisms could have 
a substantial impact on the environment. 
Section IV-C-1 of the draft EIS, which is entitled 
"Description of Issues Raised by Recombinant DNA Research: 
10 
Appendix K--136 
