3 
® We are apprehensive about problems of setting 
standards for regulation of industrial applications 
of the new technology expected to flow from 
recombinant DNA research. 
® Neither the EIS nor guidelines adequately discuss 
environmental spill contingency plans. 
Reflecting on our substantive concerns about expanding 
recombinant DNA research we have rated this draft EIS as 
ER-2 (an explanation of EPA's rating system for draft EIS's 
is enclosed) . The date and rating of our comments will be 
published in the Federal Register in accordance with our 
responsibilities under section 309 of the Clean Air Act, as 
amended . 
Our detailed suggestions for improvements and clarifications 
of certain points in the EIS are enclosed. If you have 
any questions concerning these comments, please contact 
Mr. Pope A. Lawrence of my staff at 245-3006. 
Sincerely yours. 
Rebecca W. Hanmer 
Director 
Office of Federal Activities (A-104) 
Enclosures 
1. Detailed Comments on NIH's DEIS for Guidelines 
for Research Involving Recombinant DNA Molecules 
2. EPA's Rating Sheet 
Appendix K — 160 
