-4- 
guidelines to notify NIH in writing of any serious or extended 
illness or accident that may result in serious exposure 
to man or to the environment so that a judgement can be made 
regarding increase in safeguards or to stop experiments. This 
reporting function is appropriate, but it occurs to us that 
in the case of a serious accident or spill then a more 
adequate em.ergency procedure for protection of the public is 
needed. It seems possible that an inordinate amount of time 
might be required to confirm a case of laboratory-caused 
infection before remedial action would be taken. 
Page 69-71. The model for analyzing the probability of 
dispersion of potentially hazardous agents is an appropriate 
exercise, but in the absence of real data with which to 
assess the relevant probabilities, we are uncomfortable. We 
note that NIH is currently supporting research to improve 
ability to evaluate certain of those probabilities. 
Appendix K — 164 
