♦ ♦ ♦ TABLE OF CONTENTS ♦ ♦ * 
I. Call to Order 5 
II. RAC Working Group Report - Data Management 6 
III. December 2-3, 1993, Recombinant DNA Advisory Committee Minutes 7 
IV. Chair Report on Minor Modifications to NIH-Approved Human Gene 
Transfer Protocols 7 
V. Addition to Appendix D of the NIH Guidelines Regarding a Human 
Gene Transfer Protocol Entitled: A Phase I Study of Immunization 
with Gamma Interferon Transduced Neuroblastoma Cells /Dis. Rosenblatt 
and Seeger 8 
VI. Addition to Appendix D of the NIH Guidelines Regarding a Human Gene 
Transfer Protocol Entitled: A Phase //// Pilot Study of the Safety 
of the Adoptive Transfer of Syngeneic Gene-Modified Cytotoxic T- 
Lymphocytes in HIV-Infected Identical Twins /T>r. Walker 11 
VII. Addition to Appendix D of the NIH Guidelines Regarding a Human Gene 
Transfer Protocol Entitled: Expression of an Exogenously Administered 
Human Alpha- 1 Antitrypsin Gene in the Respiratory Tract of Humans 
/Dr. Brigham 17 
VIII. Addition to Appendbc D of the NIH Guidelines Regarding a Human Gene 
Transfer Protocol Entitled: Use of a Retroviral Vector to Study the 
Trafficking Patterns of Purified Ovarian Tumor Infiltrating Lymphocytes 
(TIL) Used in Intraperitoneal Adoptive Immunotherapy of Ovarian Cancer 
Patients - A Pilot Study /Or. Freedman 20 
IX. Report from the RAC Working Group on Vaccines-Amendments to Footnote 
21 of the NIH Guidelines Regarding the Definition of Recombinant DNA 
Vaccines/Dr. Post 24 
X. Report from the RAC Working Group on Accelerated i?ev/ew-Amendment to 
the NIH Guidelines and the Points to Consider Regarding Accelerated 
Review of Human Gene Transfer Protocols/Dr. Parkman 26 
XI. Addition to Appendix D of the NIH Guidelines Regarding Deliberate 
Transfer of a Chloramphenicol Resistance Gene to an Avirulent Strain 
of Rickettsia Prowazeld/Ov. Policastro 30 
Recombinant DNA Research, Volume 19 
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