5 . Since this tumor cell preparation has never been previously tested in humans there could be 
toxic effects that could occur of which we are currently unaware. 
Potential Benefits 
There is no guarantee that this treatment will have any beneficial effects against my (my 
child/ward's) tumor. The potential benefit of the program is to inhibit the growth and spread of 
neuroblastoma, but the response of any patient may vary and I (my child/ward) might not 
respond to this treatment program. As a phase one study, this study is primarily designed to 
determine the maximum tolerated dose of the treatment that is still found to have manageable 
side effects. Therefore, it is possible that you (your child/ward) might receive a dose of tumor 
cells below the dose which may have the most tumor action. Considerable knowledge should 
be gained from this study program to allow us to design future studies involving the use of 
genetically engineered tumor cells, and this knowledge may help you (your child/ward) and/or 
other children by improving the treatment of this and other cancers if the future. It is also quite 
possible that you (your child/ward) will receive no direct benefit from participation in the 
study. 
Alternative Therapies 
This program uses a new experimental approach for the treatment of neuroblastoma. The 
alternative is to continue with other investigational therapies such as alternative forms or 
combinations of chemotherapy, and/or radiation, or to give no further therapy other than 
supportive care. These options, including supportive care to keep me (my child/ward) 
comfortable, will not be affected by a decision to enter or withdraw from this treatment 
program. 
Right to Refuse or Withdraw 
I understand that I (my child/ward) have the right to refuse to participate and/or withdraw from 
this research at any time without prejudice to my (my child/ward's) future care at UCLA. I 
understand that circumstances may arise which might cause the investigator to terminate my 
(my child/ward's) participation before completion of the study. The investigator will provide 
me with new information developed during the course of the study that might influence my 
desire to continue my participation. 
Costs 
I understand that I and my insurance carrier are financially responsible for all x-rays, laboratory 
tests, hospital and or physician fees required for routine clinical care/follow-up during the 
course of the study. The tumor cell preparation will be prepared and genetically engineered to 
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