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function and special blood tests to measure the immune function of you {your child). 
The blood tests done to measure immune function will be done at week 0 (before the 
first injection) and at weeks 8, 24, and 36. The immune function tests require 
approximately 20 cc (4 teaspoons) of blood from you (your child). All blood tests are 
drawn by vein or through a venous access device. Other tests done during this 
treatment program include scans and radiologic evaluations to follow disease status. 
All patients will have a bilateral (from both sides) bone marrow aspirate at week 0, 
before the first injection. Repeat bone marrow examinations will be done if needed 
to care for you (your child) or at weeks 8, 24, and 36 if your (your child's) bone 
marrow test was positive for tumor cells at study entry, All these tests are needed 
to measure your (your child's) clinical condition and progress. 
If any tumor cells are obtained from you (your child) during necessary follow-up tests, 
they may also be used for research purposes, including growing them continuously in 
test tubes (cell lines), unless you (your child) request otherwise. 
POTENTIAL RISKS 
Injecting gamma interferon modified neuroblastoma cells can possibly cause damage 
to normal tissues. These unpleasant or harmful side effects are called toxicities. 
Adjustments of dosage and schedule may be possible to avoid severe side effects. 
Problems which do arise are usually reversible when the treatment is stopped, but 
occasionally can persist and may cause serious complications. The following kinds 
of side effects or problems may occur with this treatment program. 
1 . Allergic reactions such as a rash, skin tenderness, swelling, fever or hives. 
More severe allergic reactions include shortness of breath, low blood pressure 
or fainting. 
2. Pain, bruising or infection at the injection site(s). 
3. Decreased energy, fatigue, joint pains, and fever. 
4 . Immune system attack on your (your child's) own body (autoimmune reaction). 
This may cause symptoms such as skin rashes, fever, joint pains, enlarged 
lymph glands, and abnormalities of the nervous system, the kidneys, and the 
liver. 
5. Tumor cells obtained from you (your child's) own body will be used if possible, 
since they may work the best to activate your (your child's) immune system 
against your (your child's) own tumor cells. However, if gamma interferon 
modified tumor cells can not be prepared from you (your child), then another 
child's neuroblastoma cells will be used. It is possible that neuroblastoma cells 
from another child will not work as well. 
6. There is a rare possibility that injection of gamma interferon modified 
neuroblastoma cells could cause a second cancer to develop in you (your child). 
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