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This second cancer would be a different cancer from neuroblastoma. 
7. There is a rare possibility that the modified tumor cells could grow in your (your 
child's) body, and become a neuroblastoma tumor. To prevent this, tumor cells 
are treated with radiation before they are injected into you (your child). 
8. There is a rare possibility that a hardened, red, and irritated lump (granuloma) 
may form at the injection site, and that this may require a cut of the skin to 
drain. If it occurs, the lump should resolve within a few weeks after stopping 
therapy. 
9. The effect of this treatment on bearing children is not known. Although 
patients who have previously received chemotherapy and irradiation may be 
unable to have children, those who participate in this study who of childbearing 
age will need to use birth control measures until three months after the last 
injection of modified tumor cells. 
It is also possible that injecting gamma Tnterferon modified tumor cells could cause 
side effects that we currently do not know about since this treatment has not been 
previously tested in humans. 
ALTERNATIVES 
This program is testing a new experimental approach that may kill neuroblastoma cells 
that have grown despite more conventional therapies. The alternatives are 
observation, with no further therapy, or other investigational therapies. Supportive 
care to keep you (your child) comfortable is always available and will not be affected 
by a decision to enter or withdraw from this treatment program. 
PHYSICAL INJURY 
The possible risks associated with this study plan have been presented. There is 
always the possibility that physical injury may occur. The Childrens Hospital Los 
Angeles maintains professional liability insurance to protect patients from financial 
losses resulting from physical injury caused through the fault of the hospital, its 
employees or its agents. If physical injury occurs in the absence of such fault, the 
hospital does not provide reimbursement for treatment expenses or other 
compensation for physical injury suffered as a result of your(your child's) participation 
in this study. 
If you believe that physical injury has been suffered as a result of participation in this 
study, you(your child) should contact Dr. Robert Seeger at (213) 669-5618. 
Treatment for such injury will be available under the same financial arrangement as 
treatment is usually provided. 
CONFIDENTIALITY 
Recombinant DNA Research, Volume 19 
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