Table of Contents 
RAC Application 
Kenneth L. Brigham, M.D. 
TABLE OF CONTENTS 
Scientific Abstract 3 
Non-Technical Abstract 4 
IRB/IBC Approvals 5-11 
Points to Consider 
Applicability 12 
Introduction 12 
Description of Proposal 
A. Objectives and Rationale 13 
B. Research Design, Risks, and Benefits 13-15 
C. Selection of Patients 15 
D. Informed Consent 15-16 
E. Privacy and Confidentiality 16 
Special Issues 
A. Provision of Information 16 
B. Communication of Research Methods and Results 16 
Protocol 17-34 
Informed Consent Documentation 35-41 
Appendixes 
Appendix A - Vector Information Al-All 
Appendix B - IRB/IBC Applications B1-B39 
Appendix C - IND Application C1-C20 
Appendix D - Supporting Publications D1-D91 
Curricula Vitae 
Recombinant DNA Research, Volume 19 [173] 
