Curricula Vitae 
RAC Application 
Kenneth L. Brigham, M.D. 
Research and Professional Experience (Continued) 
1988 Visiting Scientist, Department of Molecular Physiology and Biophysics, Vanderbilt University 
School of Medicine, Nashville, Tennessee (January through June, 1988) 
Publications (Selected): 
1. Brigham, K.L., Stahlman, M.T., Eds. Respiratory Distress Syndrome: Molecules to Man . Vanderbilt 
Univ. Press, Nashville, TN, 1990. 
2. Perkett, E.A., Lyons, R.M., Moses, H.L., Brigham, K.L., Meyrick, B. Transforming growth factor-/3 
activity in sheep lung lymph during the development of pulmonary hypertension. J. Clin. Invest. 
86:1459-1464, 1990. 
3. Johnson, J., Brigham, K.L., Meyrick, B. Morphological changes in lungs of anesthetized sheep 
following intravenous infusion of recombinant human tumor necrosis factor alpha. Am. Rev. Respir. 
Pis. 144:179-186, 1991. 
4. Brigham, K.L., Canonico, A.E., Conary, J.T. Mediator gene expression in sepsis: Implications for 
therapy. In: Update in Intensive Care and Emergency Medicine, Volume 16: Mediators of Sepsis. 
Springer-Verlag, 1992, pp. 393-405. 
5. Brigham, K.L., Meyrick, B., Christman, B., Conary, J., King, G., Berry, L.C., Jr., Magnuson, M. 
Expression of human growth hormone fusion genes in cultured lung endothelial cells and in the lungs 
of mice. Am. J. Respir. Cell Molec. Biol. 8(2):209-213, 1993. 
6. Brigham, K.L., Schreier, H. Cationic Liposomes and DNA Delivery. J. Liposome Res. 3(l):31-49, 
1993. 
7. Canonico, A.E., Brigham, K.L. In vivo expression of human genes. Current Opinion in Therapeutic 
Patents . 3(10):1487-1498, 1993. 
8. Canonico, A.E., Conary, J.T., Meyrick, B.O., Brigham, K.L. Cationic liposome mediated in vivo 
transfer of human alpha-1 antitrypsin gene to lungs of rabbits. Am. J. Respir. Cell Mol. Biol. 10:24-29. 
In Press, 1993. 
9. Bernard, G.R., Brigham, K.L. Chapter 78: Pulmonary edema. Internal Medicine, J.H. Stein, Editor, 
4th Edition, Little Brown and Co., j^ston, MA. (Revision of 3rd edition, 1989, pp. 649-654). In Press, 
1993. 
10. Brigham, K.L., Editor: Endotoxin and the Lungs . Volume in the Series: Lung Biology in Health and 
Disease, C. Lenfant, Ed., Marcel Dekker, Inc. In Press, 1993. 
11. Brigham, K.L., Canonico, A.E., Meyrick, B.O., Conary, J.T., Schreier, H. Prospects for gene therapy 
for endotoxin induced lung injury. In: Endotoxin and the Lungs . K.L. Brigham, Ed., Marcel Dekker, 
Inc. In Press, 1993. 
12. Brigham, K.L., Canonico, A.E., Conary, J.T., Meyrick, B.O., Shreier, H. Potential for gene therapy in 
the treatment of sepsis. Chapter in the Series: "Update in Intensive Care and Emergency Medicine." 
Vincent, J.L., Series Editor. Springer-Verlag. In Press, 1993. 
13. Brigham, K.L., Canonico, A.E., Meyrick, B.O., Schreier, H., Stecenko, A. A., Conary, J.T. Gene therapy 
for inflammatory diseases. In: Bacterial Endotoxins: Basic Science to Anti-Sepsis Strategies ; 
Proceedings of the International Conference on Endotoxins IV, Amsterdam, August, 1993. J. Levin, 
A. Sturk, T. van der Poll, S.J.H. van Deventer, Eds., John Wiley & Sons, Inc., New York. In Press, 
1993. 
14. Conary, J.T., Parker, R.E., Christman, B.W., Faulks, R.D., King, G., Meyrick, B.O., Brigham, K.L. 
Protection of rabbit lungs from endotoxin injury by ]n vivo hyperexpression of the prostaglandin G/H 
synthase gene. J. Clin. Invest. Submitted, 1993. 
15. Rummel, R., Conary, J., Parker, R., Christman, B., Quertermous, T., Brigham, K. Endothelin-1 in the 
vascular response to endotoxin in sheep. J. Appl. Physiol. Submitted, 1993. 
16. Canonico, A.E., Plitman, J.D., Conary, J.T., Meyrick, B.O., Brigham, K.L. Repeated intravenous or 
aerosol administration of plasmid-liposome complexes causes prolonged expression of human alpha-1 
antitrypsin in rabbit lung without toxicity. J. Appl. Physiol. Submitted, 1993. 
Recombinant DNA Research, Volume 19 
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