Non-technical Abstract 
Non-Technical Abstract 
Many types of cancer cannot be cured by traditional medical treatments, including drugs, 
surgery, or radiation. In this study, an experimental treatment will be offered that may help to 
fight this disease. We will attempt to induce tumor regression by the introduction of genetic 
material that directs the synthesis of proteins which stimulate the immune system. The genetic 
material, DNA, will be introduced directly into the tumor by mixing it with fatty substances, or 
lipids, and this mixture will be injected into the tumor. The DNA will be taken into cells and 
cause them to produce proteins that stimulate tissue rejection. These proteins, called 
histocompatibility proteins, cause cells which contain it to be recognized as foreign by the 
immune system. The goal of the treatment is to stimulate the immune system to attack and kill 
the tumor. In this study, we will attempt to determine the optimal safe and effective dose to 
administer the DNA/lipid complex. Increasing amounts of this complex will be used in 
different patient populations. If no side effects are observed, repeated treatments may be 
instituted. The expression and nature of the immune response will also be characterized. This 
treatment may provide a therapeutic effect in cancer and could be applied to the treatment of 
other diseases. 
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Recombinant DNA Research, Volume 19 
