Phase I Study of Immunotherapy of Metastatic Renal Cell Carcinoma 
by Direct Gene Transfer Into Metastasic Lesions 
Protocol 
(This protocol is identical in background, goals, patient monitoring, and drug preparation 
and supply as the master protocol "Phase I/n Trial of HLA-B7 Plasmid 
DNA/DMRIE/DOPE Complex as an Immuno therapeutic Agent in Solid Malignant tumors 
by Direct Gene Transfer." In addition, it contains the details of patient eligibility and 
treatment specific to a study of metastatic renal cell carcinoma proposed by and to be 
carried out at the University of Chicago.) 
Principal Investigator: 
Co-Investigators: 
Sponsor: 
Date: 
Nicholas J. Vogelzang, M.D. 
Timothy M. Lestingi, M.D. 
Gary Sudakoff, M.D. 
Vical Inc. 
December 20, 1993 
Recombinant DNA Research, Volume 19 
[205] 
