THE UNIVERSITY OF TEXAS 
M. D. ANDERSON CANCER CENTER 
Protocol 
Protocol Title: "Clinical Protocol for Modification of Oncogene and Tumor Suppressor Gene 
Expression in Non-Small Cell Lung Cancer (NSCLC)" 
Abstract 
1.0 
Objectives 
Page 
2.0 
Background and Rationale 
Page 
3.0 
Safety Information 
Page 
4.0 
Patient Eligibility 
Page 
5.0 
Treatment Plan 
Page 
6.0 
Pre-Treatment Evaluation 
Page 
7.0 
Evaluation During Study 
Page 
8.0 
Criteria for Response and Toxicity 
Page 
9.0 
Criteria for Discontinuing Therapy 
Page 
10.0 
Data and Protocol Management 
Page 
1 1.0 
Reporting Requirements 
Page 
12.0 
References 
Page 
Appendix A: Evaluation Before and During Therapy 
Appendix B: Zubrod Scale of Performance Status 
Appendix C: Toxicity Criteria 
Appendix D: Informed Consent 
STUDY CHAIRMAN: 
rf,P. 
Jack A. Roth, M.D. 
Department of Thoracic Surgery 
[274] 
Recombinant DNA Research, Volume 19 
