* ♦ ♦ TABLE OF CONTENTS ♦ ♦ ♦ 
I. Call to Order/Dr. Walters 5 
II. Chair Report on Minor Modifications to NIH-Approved Human Gene 
Transfer Protocols/Dr. Walters 8 
m. March 3-4, 1994, Recombinant DNA Advisory Committee Minutes 8 
rV-A. Addition to Appendix D of the NIH Guidelines Regarding a Human 
Gene Transfer Protocol Entitled: Phase I Trial of a Polynucleotide 
Augmented Antitumor Immunization to Human Carcinoembryonic Antigen 
in Patients with Metastatic Colorectal Cancer IT>i. Curiel 8 
rV-B. Announcement of FDA Sponsored Meeting 15 
V. Addition to Appendix D of the NIH Guidelines Regarding a Human 
Gene Transfer Protocol Entitled: Clinical Trial to Assess the 
Safety, Feasibility, and Efficacy of Transferring a Potentially 
Anti-Arthritic Cytokine Gene to Human loints with Rheumatoid 
Arthritis /T>is. Evans and Robbins 15 
VI. Addition to Appendbc D of the NIH Guidelines Regarding a Human 
Gene Transfer Protocol Entitied: Use of a Retroviral Vector to 
Study the Trajficking Patterns of Purified Ovarian TIL 
Populations Used in Intraperitoneal Adoptive Immunotherapy of 
Ovarian Cancer Patients: A Pilot Study /D t. Freedman 20 
Vn. Addition to Appendix D of the NIH Guidelines Regarding a Human 
Gene Transfer Protocol Entitled: Use of Double Marking with 
Retroviral Vectors to Determine the Rate of Reconstitution of 
Untreated and Cytokine Expanded CD34( + ) Selected Marrow Cells 
in Patients Undergoing Autologous Bone Marrow Transplantation 
/Drs. Heslop, Brenner, and Krance 22 
VIII. Working Group on Data Management"Semi-Annual Data Management 
Report/Dr. Smith 24 
IX. Addition to Appendbc D of the NIH Guidelines Regarding a Human 
Gene Transfer Protocol Entitled: Use of Safety-Modified 
Retroviruses to Introduce Chemotherapy Resistance Sequences into 
Normal Hematopoietic Cells for Chemoprotection During the Therapy 
of Breast Cancer: A Pilot Trial /Dis. Deisseroth, Hortobagyi, 
Champlin, and Holmes 26 
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