Recombinant DMA Advisory Committee - 6/9-10/94 
abstentions. 
Appendix L will be deleted as follows: 
"APPENDIX L. RELEASE INTO THE ENVIRONMENT OF CERTAIN PLANTS 
""Appendix L-I. General Information 
""Appendix L specifies conditions under which certain plants as specified below, may be 
approved for release into the environment. Experiments in this category cannot be 
initiated without submission of relevant information on the proposed experiment to NIH, 
review by the RAC Plant Working Group, and specific approval by the NIH Director. 
Such experiments also require the approval of the IBC before initiation. Information on 
specific experiments which have been approved will be available in ORDA and will be 
listed in Appendix L-in when the Guidelines are republished. 
""Experiments which do not meet the specifications of Appendix L-H fall under Section 
III-A and require RAC review and NIH and IBC approval before initiation. 
""Appendix L-II. Criteria Allowing Review by the RAC Plant Working Group Without the 
Requirement for Full RAC Review. 
""Approval may be granted by ORDA in consultation with the Plant Working Group 
without the requirement for full RAC review (IBC review is also necessary) for growing 
plants containing recombinant DNA in the field under the following conditions: 
""Appendbc l^II-A. The plant species is a cultivated crop of a genus that has no species 
known to be a noxious weed. 
""Appendix L^II-B. The introduced DNA consists of well-characterized genes containing 
no sequences harmful to humans, animals, or plants. 
""Appendix I^II-C. The vector consists of DNA: (i) From exempt host-vector systems 
(see Appendix C); (ii) from plants of the same or closely related species; (iii) from 
nonpathogenic prokaryotes or nonpathogenic lower eukaryotic plants; (iv) from plant 
pathogens only if sequences resulting in production of disease symptoms have been 
deleted; or (v) chimeric vectors constructed from sequences defined in (i) to (iv) above. 
The DNA may be introduced by any suitable method. If sequences resulting in 
production of disease symptoms are retained for purposes of introducing the DNA into 
the plant, greenhouse-grown plants must be shown to be free of such sequences before 
such plants, their derivatives, or seed can be used in field tests. 
""Appendix L-II-D. Plants are grown in controlled access fields under specified conditions 
appropriate for the plant under study and the geographical location. Such conditions 
should include provisions for using good cultural and pest control practices, for physical 
isolation from plants of the same species outside of the experimental plot in accordance 
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