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9202-015 
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9202-017*’ 
9206-018 
9206-019* 
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9206-023* 
(T) Rosenberg, Steven A., National Institutes of Health, BethesOa, Maryland; Immunization of Cancer Patients Using Autologous Cancer 
Cells Modified by Insertion of the Gene for Inierleukin-2 (IL~2). 
RAC Approval; 10-7-91/NIH Approval: 10-15-91 
(T) Wilson, James M., University of Pennsylvania Medical Cenyrt, Philadelphia, Pennsylvania; Ex Vivo Gene Therapy of Familial 
Hypercholesterolemia. 
RAC Approval: 10-8-91/NIH Approval: 11-14-91 
Minor Modification: 12-3-92 
Minor Modification; 8-18-93 
(T) Nabel, Gary J., University of Michigan, Ann Arbor, Michigan; Immunotherapy of Malignancy by In Vivo Gene Transfer into Tumors. 
RAC Approval; 2-10-92/NIH Approval: 4-17-92 
Minor Modification; 1-22-93 
Minor Modification; 1-93 
CLOSED: 11-19-92 
(M) Cometta, Kenneth, Indiana University, Indianapolis, Indiana; RetroviraJ-Mediated Gene Transfer of Bone Marrow Cells during 
Autologous Bone Marrow Transplantation for Acute Leukemia. 
RAC Approval: 2-11-92/NIH Approval: 4-17-92 
(M) Economou, James S. and Belldegrun, Arie, University of California at Los Angeles, Los Angeles, California; The Treatment of 
Patients with Metastatic Melanoma and Renal Cell Cancer Using In Vitro Expanded and Genetically-Engineered (Neomycin 
Phosphotransferase) Bulk, CDS (+) and/or CD4(-k) Tumor Infiltrating Lymphocytes and Bulk, CD8(+) and/or CD4(+) Peripheral 
Blood Leukocytes in Combination with Recombinant lnterleukin-2 Alone, or with Recombinant InterleuJdn-2 and Recombinant Alpha 
Iruerferon. 
RAC Approval: 2-1 1-92/NtH Approval: 4-lY-92 
(T) Freeman, Scott M., Tulane University Medical Center, New Orleans, Louisiana; Gene Transfer for the Treatment of Cancer. 
RAC Approval: 2-10-92/NIH Approval: 2-5-93 
Minor Modification: 8-6-93 
(M) Greenberg, Philip D. and RiddeU, Stanley, Fred Hutchinson Cancer Research Center, University of Washington, Seattle; Phase I 
Study to Evaluate the Safety of Cellular Adoptive Immunotherapy using Genetically Modified CDS + HIV-Specific T Cells in HTV 
Seropositive Individuals. 
RAC Approval: 2-11-92/NIH Approval: 4-17-92 
Major Amendment/RAC Approval 9-9-93 
Major Amendment/NIH Approval 10-7-93 
(T) Brenner, Malcolm 1C; Furman, Wayne; Santana, Victor, Bowman, Laura; and Meyer, William, St Jude Children’s Research 
Hospital, Memphis, Tennessee; Phase I Study of Cytokine -Gette Modified Autologous Neuroblastoma Cells for Treatmeru of 
Relapsed/Refractory Neuroblastoma. 
RAC Approval 6-1-92/NlH Approval; 8-14-92 
(T) Oldfield, Edward, National Institutes of Health, Bethesda, Maryland; Gene Therapy for the Treatmeru of Brain Tumors Using Intra- 
Tumoral Transduction with the Thymidine Kinase Gene and Intravenous Ganciclovir. 
RAC Approval: 6-1-92/NIH Approval 8-14-92 
Minor Modification: 11-29-93 
(M) Deisseroth, Albert B,, MD Anderson Cancer Center, Houston, Texas; Use of Two Retroviral Markers to Test Relative Contribution of 
Marrow and Peripheral Blood Autologous Cells to Recovery After Preparative Therapy. 
RAC Approval 6-2-92/NIH Approval 8-14-92 
Minor Modification; 4-19-93 
QT) Gansbacher, Bcmd; Houston, Alan; and Livingston, Philip, Memorial Sloan Kettering Cancer Center, New York, New York; 
Immunization with HLA-A2 matched Allogeneic Melanoma Cells that Secrete Interieukin-2 in Patients with Metastatic Melanoma. 
RAC Approval: 6-2-92/NIH Approval: 8-14-92 
(T) Gansbacher, Bemd; Motzer, Robert; Houston, Alan; and Bander, Neil, Memorial Sloan Kettering Cancer Center, New York, New 
York; Immunization with Interieukin-2 Secreting Allogeneic HLA-A2 Matched Renal Cell Carcinoma Cells in Patients with Advanced 
Renal Cell Carcinoma. 
RAC Approval: 6-2-92/NIH Approval: 8-14-92 
Minor Modification: 3-31-93 
(M) Dunbar, Cynthia, National Institutes of Health, Bethesda, Maryland; Retroviral-Mediated Gene Transfer of Bone Marrow and 
Peripheral Blood Stem Cells During Autologous Bone Marrow Transplantation for Multiple Myeloma. 
RAC Approval 6-2-92/NIH Approval 8-14-92 
Minor Modification: 1-6-94 
Minor ModificationL 3-23-94 
Recombinant DNA Research, Volume 19 
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