Attachment 2 - Page 4 
92U-036* 
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9303-040 
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9303-042* 
3306^43 
9306-044* 
93064MS 
9306-046 
9306-047 
93064M8 
93064)49 
(T) Welsh, Michael Howard Hughes Medical Institute, Iowa Qty, Iowa, and Smith, Alan E., Genzyme Corporation, Framingham 
Massachusetts; Cystic Fibrosis Gene Therapy Using an Adenovirus Vector: In Vivo Safety and Efficacy in Nasal Epithelium 
RAC Approval: 12-4-92/NIH Approval: 4-1693 
Minor Modificatioa: 161693 
(T) Culver, Kenneth W, Iowa Methodist Medical Center, Des Moines, Iowa, and Van Gilder, John Q; University of Iowa, Iowa City 
Iowa; Gene Therapy for the Treatment of Malignant Brain Tumors with In Vivo Tumor Transduction with the Herpes Simplex Thymidv 
Kinase Gene/Ganciclovir System. 
RAC Approval: 3-1-93/NIH Approval: 4-1693 
(M) Heslop, Helen E,; Brenner, Malcolm K,; and Rooney, Qiona, St. Jude Children’s Research Hospital, Memphis, Tennessee; 
Admirustration of Neomycin Resistance Gene Marked EBV Specific Cytotoxic T Lymphocytes to Recipients of MisTnatched-Relaied or 
PheruttypicaUy Simitar Unrelated Donor Marrow Grafts. 
RAC Approval: 3-2-93/NlH Approval: 4-1693 
(M) Brenner, Malcolm IC; Krance, Robert; Heslop, Helen E.; Santana, Victor, and Ihle, James, Sl Jude Children’s Research Hospital 
Memphis, Tennessee; Assessment of the Efficacy of Purging by Using Gene-Marked Autologous Marrow Transplantahon for Children 
with Acute Myelogenous Leukemia In First Complete Remission. 
RAC Approval; 3-2-93/NIH Approval: 4-1693 
(T) Simons, Jonathan, Johns Hopkins Oncology Center, Baltimore, Maryland; Phase I Study of Non-Replicating Autologous Tumor Cell 
Irjecdons Using Cells Prepared With or Without Granulocyte-Macrophage Colony Stimulating Factor Gene Transduction in Patients v 
Metastatic Renal Cell Carcinoma. 
RAC Approval 3-1-93/NIH Approval: 12-2-93 
(T) Wilmott, Robert W. and Whitsett, Jeffrey, Children’s Hospital Medical Center, Cincinnati, Ohio, and Trapnell, Bruce; Genetic 
Therapy, Inc, Gaithersburg, Maryland; A Phase I Study of Gene Therapy of Cystic Fibrosis Utilizing a Replication Deficient 
Recombinant Adenovirus Vector to Deliver the Human Cystic Fibrosis Transmembrane Conductance Regulator cDNA to the Airways. 
RAC Approval: 3-2-93/NlH Approval: 4-1693 
(T) Boucher, Richard C and Knowles, Michael R., University of North Carolina, Chapel Hill, North Carolina; Gene Therapy for Cyst 
Fibrosis Using El Deleted Adenovirus: A Phase I Trial in the Nasal Cavity. 
RAC Approval 3-2-93/NIH Approval 167-93 
Minor Modification: 1-17-94 
(T) Seigter, Hilliard Duke University Medical Center, Durham, North Carolina; A Phase I Trial of Human Gamma Interferon- 
Transduced Autologous Tumor Cells In Patients With Disseminated Malignant Melanoma. 
RAC Approval: 67-93/NIH Approval 9-693 
(T) Deisseroth, Albert B.; Kavanagh, Johrt; and Champlin, Richard, University of Texas MD Anderson Cancer Center, Houston, Tex 
Use of Sefety-Modifed Retroviruses to Introduce Chemotherapy Resistance Sequences into Normal Hematopoietic Cells for 
Chemoprotecdon During the Therapy of Ovarian Cancer: A Pilot Trial. 
RAC Approval 67-93/NIH Approval: 16693 
Minor Modification: 62694 
Minor Modification; 62694 
(T) Nabel, Gary J^ University of Michigan Medical Center, Ann Arbor, Michigan; Immunotherapy for Cancer by Direct Gene Transfer 
into Tumors. 
RAC Approval 67-93/NIH Approval 9-693 
(T) Barranger, John A_, University of Pittsburgh, Pittsburgh, Pennsylvania, Gene Therapy for Gaucher Disease: Ex Vivo Gene Transfer 
arul Autologous Transplantation of CD3d(+) Cells. 
RAC Approval: 67-93/NIH Approval; 9-693 
(T) Karlsson, Stefan and Dunbar, Cynthia, National Institutes of Health, Bethesda, Maryland, and Kohn, Donald B., Childrens Hosp, 
Los Angeles, Los Angeles, California; Retroviral Mediated Transfer of the cDNAfor Human Glucocerebrosidase into Hematopoietic 
Stem Cells of Patients with Gaucher Disease. 
RAC Approval 67-93/NIH Approval: 9-693 
(T) Galpin, Jeffrey E, University of Southern California, and Casciato, Dennis A, Shared Medical Research Foundation, Tarzaw, 
California; A Prelimlruiry Study to Evaluate the Sqfety and Biologic Effects of Murine Retroviral Vector Encoding HTV-1 Genes [HIV- 
IT(V)] in Asymptomatic Subjects Infected with HTV-1. 
RAC Approval 67-93/NIH Approval 9-693 
(T) Nabel, Gary J, University of Michigan Medical Center, Ann Arbor, Michigan; A Molecular Genetic Iroervention for AIDS - Effecu 
a Trantdomlnant Negative Form of Rey. 
RAC Approval 67-93/NIH A{^toval 9-693 
Recombinant DNA Research, Volume 19 
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