Attachment 2 - Page 6 
93L2-064 
(T) 
Rubin, Joseph, Mayo Qinic, Rochester, Minnesota; Phase 1 Study of Immunotherapy of Advanced Colorectal Carcinoma by Direct 
Gene Transfer Into Hepatic Metastases. 
RAC Approval: 12-3-93/NIH Approval 4-19-94 
9312-06S 
00 
Chane. Alfred E, Universitv of Michiean. Ann Arbor. Michiean; Adoptive Immunotherapy of Melanoma with Arrivar^A 
Cells Primed In Vivo with Autologous Tumor Cells Transduced with the IL-4 Gene. 
RAC AoDroval: 12-3-93/NIH Approval: Pendin£ 
93L2-066 
OO 
Sorscher, Eric J. and Loean. James L: Universitv of Alabama, Birmineham, Alabama: Gene Therapy for Cystic Fibrosis Tisina 
Cationic Liposome Mediated Gene Transfer: A Phase I Trial of Safety and Efficacy in the Nasal Airway. 
RAC Approval: 12-3-93/NTH Approval: Pendine 
93L2-067* 
GO 
Welsh, Michael J.; Howard Hughes Medical Institute, Iowa City, Iowa; Adenovirus-Mediated Gene Transfer of CFTR to the Nasal 
Epithelium and Maxillary Sinus of Patients with Cystic Fibrosis. 
RAC Approval; 12-3-93/NIH Approval: 2-10-94 
Minor Modification: 2-17-94 
9403-068 
CD 
Rosenblatt. Joseph; Universitv of California. Los Aneeles, California; and Seeeer, Robert; Childrens Hosoital. Los Anpeles. 
California; A Phase I Study of Immunization with Gamma Interferon Transduced Neuroblastoma Cells. 
RAC Approval: 3-3-94 /NTH Approval: Pendine 
9403-069 
CD 
Walker. Robert; NIH. Bethesda, Maryland; A Phase I/TI Pilot Study of the Safety of the Adoptive Transfer of Syngeneic Gene-Modified 
Cytotoxic T-Lvmphocytes in HIV-Infected Identical Twins. 
RAC Approval: 3-3-94/NlH Approval:' Pendine 
9403-070 
CD 
Brieham. Kenneth; Vanderbilt Universitv. Nashville. Tennessee; Expression of an Exogenously Administered Hitman Alpha-1- 
Antitrypsin Gene in the Respiratory Tract of Humans. 
RAC Approval: 3-3-94/NlH Approval: Pendine 
9403-071 
CD 
Vogeliang, Nicholas; the University of Chicago, Chicago, Illinois; Phase I Study of Immunotherapy for Metastatic Renal Cell 
Carcinoma by Direct Gene Transfer into Metastatic Lesions. 
RAC Approval; 3-4-94/NlH Approval; 4-19-94 
•'403-072 
CD 
Hetsh, Evan; Arizona Cancer Center, Tuscon, Arizona; and Akporiaye; Harris; Stopeck; Unger, and Wameke; the University of 
Arizona, Tuscon. Arizona; Phase 1 Study of Immunotherapy of Malignant Melanoma by Direct Gene Transfer. 
RAC Approval; 3-4-94/NIH Approval: 4-19-94 
T 
M 
Total (T -h M) 
RAC APPROVED 
50 
22 
72 
NIH DIRECTOR APPROVED 
42 
22 
64' 
LEGEND: 
M = Human Gene Marking Protocol 
T = Human Gene Therapy Protocol 
* = Minor Modincation(s) 
' = Major Amendment(s) 
* •= The number of protocols appearing in the table are greater than the number that appears in the protocol list because of the single Expediud Review 
protocol that »-as approved by the NIH Director on 12-2&-9L 
_ •= RAC Apptoved/NIH Approval Pending 
Umf U. I9M 
Recombinant DNA Research, Volume 19 
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