Principal Investigator/Program DirecUit (Last, first, middle): CuricI, Dgivid T., M.D. 
BIOGRAPHICAL SKETCH 
Give the following information for the key personnel and consultants and collaborators. Begin with the principal 
investigator/program director. Photocopy this page for each person. 
NAME 
CURIEL, David T.,M.D. 
POSITION TITLE 
Associate Professor, Medicine 
CVs 
EDUCATION (Begin with baccalaureate or other initial professional education, such as nursing, arid include postdoctoral training.) 
INSTITUTION AND LOCATION 
DEGREE 
YEAR 
CONFERRED 
FIELD OF STUDY 
West Georgia College, Carrollton, GA 
Emory Univ. School of Medicine, Atlanta, GA 
Emory Univ. Affiliated Hospital, Atlanta, GA 
B.A. 
M.D. 
Intern 
Resident 
1974-1978 
1978-1982 
1982- 1983 
1983- 1985 
Chemistry 
Medicine 
RESEARCH AND PROFESSIONAL EXPERIENCE: Concluding with present position, list, in chronological order, previous employment, 
experience, and honors. Key personnel include the principal investigator and any other individuals who participate in the scientific development or 
execution of the project. Key personnel typically will include all individuals with doctoral or other professional degrees, but in some projects will include 
individuals at the masters or baccalaureate level provided they contribute in a substantive way to the scientific development or execution of the project. 
Include present membership on any Federal Government public advisory committee. List, in chronological order, the titles,.all authors, and complete 
references to all publications during the past three years and to representative earlier publications pertinent to this application. DO NOT EXCEED 
TWO PAGES. 
1985-1989 
1989- 1990 
1990- 1991 
1991- 1993 
1992- 1993 
1992-1993 
7/93-Present 
Fellowship, Pulmonary Medicine, Pulmonary Branch, National Heart, Lung and 
Blood Institute, National Institutes of Health, Bethesda, MD. 
Biotechnology, Navy Medical Oncology Branch, National Cancer Institute, National 
Institutes of Health, Bethesda, MD. 
Visiting Assistant Professor of Medicine, Division of Pulmonary Diseases, 
Department of Medicine, The University of North Carolina, Chapel Hill, NC. 
Assistant Professor of Medicine, Division of Pulmonary Diseases, Department of 
Medicine, The University of North Carolina, Chapel Hill, NC. 
Curriculum in Genetics, The University of North Carolina, Chapel Hill, NC. 
Member, UNC Lineberger Comprehensive Cancer Center, Chapel Hill, NC. 
Associate Professor of Medicine, Division of Pulmonary Diseases; Director, Gene 
Therapy Program; Scientist, Comprehensive Cancer Center, University of Alabama at 
Birmingham. 
SELECTED PUBLICATIONS : 
Curiel D, Laubach V, Vogelmeier C, Wurts L, Crystal RG: Characterization of the sequence of the 
normal alpha 1-antitrypsin M3 allele and function of the M3 protein. Am J Respir Cell Mol Biol 
1:471-477, 1989. 
Curiel DT, Vogelmeier C, Hubbard RC, Stier LE, Crystal RG: Molecular basis of the alpha 1- 
antitrypsin deficiency and emphysema associated with the alpha 1-antitrypsin Mmineral springs 
allele. Mol Cell Biol 10:47-56, 1990. 
Holmes MD, Brantly ML, Curiel DT, Weidinger S, Crystal RG: Characterization of the normal alpha 
1-antitrypsin allele Vmunich: A variant associated with a unique protein isoelectric focusing pattern. 
Am J Hum Genet 46:810-816, 1990. 
Chiba I, Takahashi T, Nau MM, D’Amico D, Curiel DT, Mitsudomi T, Buchhagen DL, Carbone D, 
Koga H, Reissman PT, Salmon DJ, Holmes EC, Minna JD: Mutations in the p53 gene are frequent in 
primary resected, non-small cell lung cancer. Oncogene 5:101-108, 1990. 
Curiel DT, Buchhagen DL, Chiba I, D’Amico D, Takahashi T, Minna JD: A chemical mismatch 
cleavage method useful for the detection of point mutations in the p53 gene in lung cancer. Am J 
Respir Cell Mol Biol 3:405-411, 1990. 
Recombinant DNA Research, Volume 19 
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