Principal Investigator/Program Dimclor (Last, first, middle): CuHel, DavidT., M.D. 
Curiel DT, Agarwal S, Wagner E, Gotten M: Adenovirus enhancement of transferrin-polylysine 
mediated gene delivery. Proc Natl Acad Sci USA 88:8850-8854, 1991. 
Curiel DT, Wagner E, Gotten M, Birnstiel ML, Li C-m, Loechel S, Agarwal S, Hu P-c: High efficiency 
gene transfer mediated by adenovirus coupled to DNA-polylysine complexes via an antibody bridge. 
Human Gene Ther 3:147-154, 1992. 
Curiel DT, Agarwal S, Romer N, Wagner E, Gotten M, Birnstiel M, Boucher RC: Gene transfer to 
respiratory epithelial cells via the receptor-mediated endocytosis pathway. Am J Respir Cell Mol Biol 
6:247-252, 1992. 
Zatloukal K, Wagner E, Gotten M, Phillips S, Plank C, Steinlein P, Curiel DT, Birnstiel ML: 
Transferrinfection: A highly efficient way to express gene constructs in eukaryotic cells. NY Acad Sci 
660:136-153, 1992. 
Gotten M, Wagner E, Zatloukal K, Phillips S, Curiel DT, Birnstiel ML: High efficiency receptor- 
mediated delivery of small and large (48 kb) gene constructs using the endosome disruption activity of 
defective or chemically-inactivated adenovirus particles. Proc Natl Acad Sci USA 89:6094-6098, 
1992. 
Wagner E, Zatloukal K, Gotten M, Kirlappos H, Mechtler K, Curiel DT, BirnstieLML: Coupling of 
adenovirus to polylysine-DNA complexes greatly enhances receptor mediated gene delivery and 
expression of transfected cells. Proc Natl Acad Sci USA 89:6099-6103, 1992. 
Curiel D: Adenovirus facilitation of molecular conjugate-mediated gene transfer. Prog Med Virol 
40:1-8, 1993. 
Gao L, Wagner E, Gotten M, Agarwal S, Harris C, Romer M, Miller L, Hu P-c, Curiel D: Direct in vivo 
gene transfer to airway epithelium employing adenovirus-polylysine-DNA complexes. Hum Gene 
Ther 4:17-24, 1993. 
Michael SI, Huang C-H, Romer MU, Wagner E, Hu P-c, Curiel DT: Binding-incompetent adenovirus 
facilitates molecular conjugate-mediated gene transfer by the receptor-mediated endocytosis 
pathway. J Biol Chem 268:6866-6869, 1993. 
Harris CE, Agarwal S, Hu P-C, Wagner E, Curiel DT: Receptor-mediated gene transfer to airway 
epithelial cells in primary culture. J Respir Cell Mol Biol 9:441-447, 1993. 
Garver RI Jr, Goldsmith KT, Rodu B, Hu P-C, Sorscher EJ, Curiel DT: Strategy for achieving 
selective killing of carcinomas. Gene Therapy, 1993. In press 
Lori F, Lisziewicz J, Smythe J, Cara A, Bunnag T, Curiel DT, Gallo R: Rapid protection against 
human immunodeficiency virus type 1 (HIV-1) replication mediated by high efficiency non-retroviral 
delivery of genes interfering with HIV-1 tat and gag. Gene Therapy, 1993. In press 
Lozier JN, Thompson AR, Hu P-C, Read MA, Brinkhous KM, High KA, Curiel DT: Efficient 
transfection of primary cells in a hemophilia B model using adenovirus moelcular conjugates. Hum 
Gene Ther, 1993. In press 
Cook DR, Maxwell I, Glode LM, Maxwell F, Stevens JA, Wagner E, Curiel DT, Curiel TJ: Gene 
therapy for B-cell lymphoma in a SCID mouse model using an immunoglobulin-regulated diphtheria 
toxin gene delivered by a novel adenovirus vector. In press 
Curiel TJ, Nicot D, Bogedain C, Jilg W, Harrison GS, Gotten M, Curiel DT, Wagner E: Efficient 
foreign gene expression in Epstein-Barr virus transformed human B-cells. Virology, 1994. In press 
Conry RM, LoBuglio AF, Kantor J, Schlom J, Loechel F, Moore SE, Sumerel LA, Barlow DL, Abrams 
S, Curiel DT: Immune response to a carcinoembryonic antigen polynucleotide vaccine. Cancer Res 
54:1164-1168,1994. 
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