14. Arend, W.P. and Dayer, J.M. (1990) Cytokines and cytokine inhbitors or antagonists 
in rheumatoid arthritis. Arthritis Rheum. 33:305-315. 
15. Pettipher, E.R., Higgs, G.A. and Henderson, B. (1986) Interleukin-1 induces 
leukocyte infiltration and cartilage breakdown in the synovial joint. Proc. Natl. Acad. 
Sci. USA 83:8749-8753. 
16. McDonnell, J., Hoernner, L.A., Lark, M.W., Harper, C., Dey, T., Lobner, J. (1992) 
Recombinant interleukin- 1/3 induced increase in levels of proteoglycans, stromelysin and 
leukocytes in rabbit synovial fluid. Arthritis Rheum. 35:799-805. 
17. Arner, E.C., DiMeo, T.M., Ruhl, D.M. and Pralta, M.A. (1989) In vivo studies on 
the effects of human recombinant interleukin-1/3 on articular cartilage. Agents Actions 
27:254-257. 
18. Bandara, G. and Evans, C.H. (1992) Intercellular regulation by synoviocytes. In 
Biological regulation of the chondrocyte (M. Adolphe, ed. ) 205-226. CPC Press, Boca 
Raton, FL. 
19. Saklatvala, J. (1986) Tumor necrosis factor a stimulates resorption and inhibits 
synthesis of proteoglycan in cartilage. Nature 322:547-549. 
20. Nietfeld, J.J., Wilbrink, B., Den Otter, W., Huber, J. and Hiker-Bruning, O. (1990) 
The effect of human interleukin-1 on proteoglycan metabolism in human porcine 
cartilage explants. J. Rheumatol. 17:818-. 
21. Arend, W.P. (1993) Interleukin-1 receptor antagonist. Adv. Immunol. 54:167-227. 
22. Dripps, D.J., Brandhuber, B.J., Thompson, R.C. and Eisenberg, S.P. (1991) 
Interleukin-1 (IL-1) receptor antagonist binds to the 80 kDa IL-1 receptor but does not 
initiate IL-1 signal transduction. J. Biol. Chem. 266:10331-10336. 
23. Dinarello, C.A. and Thompson, R.C. (1991) Blocking II^l: inteleukin-1 receptor 
antagonist in vivo and in vitro. Immunol. Today 12:404-410. 
*24. Evans, C.H. and Robbins, Ph.D. (1994) The interleukin-1 receptor antagonist and 
its delivery by gene transfer. Receptor 4: In press. 
25. Schwab, J.H., Anderle, S.K., Brown, R.R., Dalldorf, F.G. and Thompson, R.C. (1991) 
Pro- and anti-inflammatory roles of interleukin-1 in recurrence of bacterial cell wall 
induced arthritis in rats. Infect. Immunol. 59:4436-4442. 
26. Lebsack, M.E., Paul, C.C., Bloedow, D.C., Burch, F.X., Sack, M.A., Chase, W. and 
Catalano, M.A. (1993) Subcutaneous IL-1 receptor antagonist in patients with 
Recombinant DNA Research, Volume 19 
[441] 
