PNG 
479 
945E 5fl26B 15:47 P.16 
Museuloskflelii hevf»fc^ 
Ccnici 
Chflslophrf H Fv.ln<, PhD 
•r\d 
F«iyu><.»n 
Patient 
LJllivCrSlty of PlUsburi^h Approved by Biomedical TKB 
Alctlical Chenier University of Pittsburgh on: 
Ml/si'nlo.d'r/ctfll Jiisf li/I I C OUk Wjll 
Pill?.Uur||li. r«\ I J2G I 
CJ6 lOU'J'b«H-10':);' 
Fox ^ i:/.eio 0 1 'i 
Cnn«cnf to Acl as a Subject in an Experimental Study 
Competent Adulis (IX years of age or older) 
TITLE: Clinical trial to assess the safety, feasibility and efficacy of 
transfenlng a potentially an(i*ar(hritic cytokine gene to human 
joints with rheumatoid aithritis 
INVESTIGATORS; C.H. Evans, Ph.D. 
Professor, Department of Orthopaedic Surgery and 
Molecular Genetics and Biochemistry 
University of Pillshiirgh School of Medicine 
Principal Investigator 
James H. Herndon, M.D., M.B.A, 
Professor and Chairman, Department Ortho. Surgery 
L'nivcrslly of Pittsburgh Medical Center 
University of Pittsburgh School of Medicine 
Co-lnvestlga(or 
Paul D. Robbins, Ph.l). 
Assistant Professor, Department of Molecular Genetics 
Biochemistry 
Univcisily of Pittsburgh School of Medicine 
Co*lnrcs(igator 
Joseph C. Glorioso, Ph.D. 
Professor and Chairman, Department, Molecular Genetics & 
Biochemistry 
University of Pittsburgh School of Medicine 
CO'Inve.stigalor 
William B. Macaulay. M.D. 
Resident, Deparlmciil of Orthopaedic Surgery 
University of Pittsburgh Medical Center 
University of Pittsburgh School of Medicine 
Co-lnvcsligator 
•SOLIRCK OF SUPPORT: National Institutes of Health 
llnlvcrsify Orthopaedics, Inc. 
Pittsburgh Genetic-S Institute 
Initiale 
Recombinant DNA Research, Volume W 
[ 443 ] 
