rF 
Principal Invesligalof/Pfografn Diroctof (Last, first, middle): 
BIOGRAPHICAL SKETCH CVs 
Give the following information lor the key personnel and consultants and coHatxDrators. Begin with the principal 
investigalor/program director. Photocopy this page for each p>erson. 
NAME 
POSITION TITLE 
Evans, Christopher H. 
Professor, Orthopaedic Surgery 
Molecular Genetics & Biochemistry 
EDUCATION (Begin with baccalaureate or other initial professional education, such as nursing, and indude postdoctoral trainirtg.) 
institution AND LOCATION 
DEGREE 
YEAR 
CONFERRED 
FIELD OF STUDY 
University of Wales, Swansea, UK 
B.Sc. 
1971 
Genetics/Microbiology 
University of Wales, Swansea, UK 
Ph.D. 1974 
Biochemistry 
Free University of Brussels, Belgium 
Post-Doc 
1974-1977 
Molecular Biology 
University of Pittsburgh, Pgh., PA 
M.A. 
1983 
Hist/Phil Science 
RESEARCH AND PROFESSIONAL EXPERIENCE: Concluding with present position, list, in chronological order, previous employment, experience, ar 
honors Key personnel include the principal investigator and any other individuals who participate in the sdentific development or execution of the proje< 
Key personnel typically will indude all individuals with doctoral or other professional degrees, but in some projects will include individuals at the masters < 
baccalaureate level provided they contribute in a substantive way to the scientific development or execution of the project Include present membership c 
any Federal Government public advisory committee. List, in chronological order, the titles, all authors, and complete references to all publications during tt 
past three years and to representative eartier publications pertinent to this application DO NOT EXCEED TWO PAGES 
Postdoctoral Research Fellow , Dept. Molecular Biology 1974-1977 
Free University of Brussels, Belgium 
Lecturer . Orthopaedic Surgery, Univ. of Pittsburgh 1978-1979 
Assistant Professor . Orthopaedic Surgery, Univ. of Pittsburgh 1979-1984 
Assistant Professor . Biochemistry (secondary appointment) 1982-1984 
Associate Professor . Orthopaedic Surgery/Molecular Genetics & Biochemistry 1984-Present 
University of Pittsburgh 
Tenure Conferred . University of Pittsburgh 1986 
Professor . Departments Orthopaedic Surgery; Molecular Genetics & Biochemistry 1993 
University of Pittsburgh 
HONORS : Kappa Delta Award (1985); Cabaud Award (1988); Research Prize, German Pain Society (1989); Fellow, 
Royal Society of Chemistry (1989); Fogarty Senior International Fellow (N.I.H.), 1990. 
PUBLICATIONS 
Watanabe, S., Georgescu, H.I., Mendelow, D., Evans, C.H.: Chondrocyte activation in response to factor(s) 
produced by a continuous line of lapine synovial fibroblasts. Exp. Cell Res. 167:218-226, 1986. 
Ferguson, G.M., Watanabe, S., Georgescu, H.I., Evans, C.H.: The synovial production of collagenase and 
chondrocyte activating factors in response to cobatt. J. Orthop. Res. 6:525-530, 1988. 
Olson, E.J., Kang, J.D., Fu, F.H., Georgescu, H.I., Mason, G.C., Evans, C.H.: The biochemical and 
histological effects of artificial ligament wear particles: In vitro and in vivo studies. Am. J. Sports Med. 
16:558-570, 1988. 
Georgescu, H.I., Mendelow, D., Evans, C.H.: HIG-82: An established cell line from rabbit periarticular soft tissue 
which retains the 'activatable' phenotype. In Vitro 24:1015-1022, 1988. 
Tsao, M., Ferrarini, M., Evans, C.H., Ambro, A., Whitside, T.L: Purification of a glycosaminoglycan (GAG)- 
stimulatory lymphokine from supernatants of in vitro stimulated human mononuclear cells. Clin. Immunol. 
Immunopathol. 50:122-131, 1989. 
Watanabe, S., Georgescu, H.I., Kuhns, D.B., Evans, C.H.: Chondrocyte activation by a putative interleukin-1 derived 
from lapine polymorphonuclear leukocytes. Arch. Biochem. Biophys. 270:69-76, 1989. 
Bandara, G., Lin, C.W., Georgescu, H.I., Mendelow, D., Evans, C.H.: Chondrocyte activation by interleukin-1: 
analysis of the synergistic properties of fibroblast growth factor and phorbol myristate acetate. Arch. 
Biochem. Biophys. 274:539-547, 1989. 
Wehling, P., Bandara, G., Evans, C.H.: Synovial cytokines impair the function of the sciatic nerve in rats: a possible 
element In the pathophysiology of radicular syndromes. Neuro-orlhop. 7:55-59, 1989. 
Hulkower, K., Georgescu, H I., Evans, C.H.: Altered patterns of protein phosphorylation in articular chondrocytes 
treated with interleukin-1 or synovial cytokines. FEBS Lett 257:228-232, 1989. 
Recombinant DNA Research, Volume 19 
