FF 
Principal Invesngator/Program Director (Last, first, middle): 
BIOGRAPHICAL SKETCH 
Give ihe following information for the key personnel and consultants and collaborators. Begin with the principal investigator/program 
director. Photocopy this page for each person. 
NAME 
POSITION imJE 
PAUL D. ROBBINS 
ASSISTANT PROFESSOR 
EDUCATION (Begin wUh baccalaureale or other initial professional education, such as nursing, and include postdoctoral training.) 
INSTITUTION AND LOCATION 
DEGREE 
YEAR 
CONFERRED 
FIELD OF STUDY 
Haverford College, Haverford, PA 
BA 
1980 
Biology 
University of California, Berkeley, CA 
Ph.D. 
1985 
Mol. Biol. 
Whitehead Institute, MIT 
Post-doc 
1990 
Mol. Biol. 
RESEARCH AND/OR PROFESSIONAL EXPERIENCE: Concluding with present positian, list in chronological order previous onploymcni, eapcriencc, and honors. Key 
personnel include the principal investigator and any other individuals who participate in the scientific development or execution of the project. Key personnel typically will 
include all individuals with doctoral or other professional de grees , but in some projects will include individuHs at the masters or baccalaureate level provided they contribute in 
a subsuntive way to the scientific development or execution of the project. Include present membership on any Federal Government public advisory commiaee. List, in 
chronological order, the titles, all authors, and complete references to all publications during the past three years and to represenutive earlier publications pertinent to this 
appEcation. IX) NOT EXCEED TWO PAGES. 
Professional Experience: 
1986-1990 Post-doctoral Fellow, Whitehead Institute for Biomedical Research, 
Cambridge, Massachusetts (Laboratory of Dr. Richard Mulligan) 
1 990-present Assistant Professor, Department of Molecular Genetics and 
Biochemistry, University of Pittsburgh School of Medicine 
1 99 1 -Present Director, Viral Vector Core Facility 
Honors and Awards 
Magill-Rhodes Scholarship, Haverford College, 1976-1980 
High Honors in Biology, Haverford College, 1980 
Jane Coffin Childs Memorial Fund for Medical Research Fellowship, 1986-1989 
Bibliography (30 representative publications out of a total of 48) 
1) Robbins, P., Rio, D. C., and M. Botchan (1986) trans activation of the simian virus 40 enhancer. Mol. 
Ce//. 5/0.6:1283-1295. 
2) Robbins, P. and M. Botchan. (1985) Promoter specificity of the SV40 enhancer: activation by T antigen. 
in Eukaryotic Transcription: the role of cis and trans-acting factors in initiation, Y. Gluzman, ed., 
eSHL 
3) Robbins, P. and M. Botchan. (1985) Trans-activation of the SV40 enhancer and late promoter by T- 
antigen. in Transcription Regulatory Factors, L. Gold and R. Calendar, ed. 
4) Robbins, P.D. (1988) Advances in gene transfer and gene therapy. Trends Biotech. 6:80-83. 
5) Lenardo, M. J., Staudt, L., Robbins, P., Kuang, A., Mulligan, R. C., and D. Baltimore. (1988) 
Repression of the immunoglobulin heavy chain enhancer in mouse teratocarcinoma cells is associated 
with the presence of a novel octamer binding factor. Science 243:544- 546 
6) Robbins, P. Horowitz, J. and R. C. Mulligan (1990) Negative regulation of c-fos expression by the 
retinoblastoma gene product. Nature 346:668-671 
7) Kim, S.-J., Lee, H.-D., Robbins, P. D., Busam, K., Spom, M. B., and A. B. Roberts. (1990) 
Regulation of TGF-Bl expression by the retinoblastoma gene product. Proc. Natl. Acad. Sci. 
88.-3052-3056. 
8) Sakai, T., Ohtani, N., McGee, T. L., Robbins, P. D., and T. P. Dryja. (1991) Oncogenic, germline 
mutations in SPl and ATF sites in the human retinoblastoma gene. Nature 353:83-86 
9) Kim, S.-J., Onwuta, U. S., Lee, Y. I., Li, R., Botchan, M. R. and P. D. Robbins. The retinoblastoma 
gene product regulates Spl -mediate transcription. Mol. Cell. Biol. 12:2455-2463. 
10) Kim, S.-J., Wagner, S., O'Reilly, M. A., Lui, F., Robbins, P.D., and M.R. Green. (1992) The 
retinoblastoma gene product activates expression of the human TGF-B2 gene through transcription 
factor ATF-2. Varwre 358:331-334 
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Recombinant DNA Research, Volume 19 
