Protocol ID93-008 
Page 18 
18. Allavena P, Zanaboni F, Rossini S. Merendino A, Bonazzi C, Vassena L, Mangioni C 
Mantovani A. Lymphokine activated killer activity of tumor-associated and peripheral blood 
lymphocytes isolated from paiients with ascites ovarian tumors. J Natl Cancer Inst 77-863- 
68. 1986. 
19. Ferrinl S. Biassoni R, Moretta A. Bruzonne M. Nicolin A. Moretta L. Clonal analysis of T 
lymphocytes Isolated from ovarian carcinoma ascitic fluid: Phenotypic and functional 
characterization of T cell clones capable of lysing autologous carcinoma cells. Int J Cancer 
36:337-43, 1985. 
20. Heo DS, \^hiiteside TL. Kanbour A, Herberman RB. Lymphocytes infiltrating human ovarian 
tumors I. role of Leu- 19 (NKHl)-positlve recombinant rll^2-actlvated cultures of lymphocytes 
infiltrating human ovarian tumors. J Immunol 140:4042-49, 1988. 
21. Aokl Y. Takakuwa K, Kodama S. Tanaka K. Takahashi M. Tokunaga A. Takahashi T. Use of 
adoptive transfer of tumor-infiltrating lymphocytes alone or in combination with clsplatin- 
contalnlng chemotherapy in patients with epithelial ovarian cancer. Cancer Res 51: 1934-39 
1991. 
22. Peoples GE. Goedegebuure PS. Andrews JVR. etc. HLA-A2 presents shared tumor- 
associated antigens derived from endogenous proteins in ovarian cancer. J Immunol 
151:5481-91, 1993. 
23. Muul LM, Nason-Burchenal K. Carter CS. Cullis H, et al. Development of an automated 
closed system for generation of human lymphokine-actlvated killer (LAK) cells for use in 
adoptive Immunotherapy. J Immunol Meth 101:171-181, 1987. 
24. Knazek RA. Wu Y-W, Aebersold PM, and Rosenberg SA. Culture of human tumor 
infiltrating lymphocytes in hollow fiber bioreactors. J Immunol Meth 127:29-37, 1990. 
25. Eggermont AM, Sugarbaker PH. Efficacy of intracavitary administration of 
cyclophosphamide, interleukin-2 and lymphokine activated killer cells against established 
Intraperltoneal tumor. Acta Med Austriaca 16:47-50, 1989. 1 
26. Stewart JA. JL Bellnson, AL Moore, et al. Phase 1 trial of intraperltoneal recombinant ' 
lnterleukln-2/lymphokine-actlvated killer cells in patients with ovarian cancer. Cancer Res 
50:6302-6310, 1990. i 
27. Stelss RG, WJ Urba, LA VanderMolen et al. Intraperltoneal lymphokine-actlvated killer-cell | 
and lnterleukln-2 therapy for malignancies limited to the peritoneal cavity. J Clin Oncol i 
8:1618-1629, 1990. 1 
28. Lembersky B, M Baldisseri, A Kunschner et al. Phase l-ll study of intraperltoneal (IP) low j 
dose lnterleukin-2 (lL-2) in refractory stage 111 ovarian cancer (OC). Proc Am Soc Clin Oncol . 
8:163, 1989, Abstract. 
29. Moreckl S, Topalian SL, Meyer WW, et al. Separation and growth of human CD4+ and CD8+ 
tumor-infiltrating lymphocytes and peripheral blood mononuclear cells by direct positive 
panning on covalently attached monoclonal antibody-coated flasks. J Biol Resp Modif 9:463, 
30. Kooi S, Freedman RS, Rodriguez-Villanueva J, and Platsoucas CD. Cytokine production by T- 
cell lines derived from tumor-infiltrating lymphocytes from patients with ovarian carcinoma. 
Tumor-specific immune responses and inhibition of antigen-independent cytokine production 
by ovarian tumor Cecils. Lyrriphokme and Cytokine Res 12:429-437,1993. 
31. Griffith KD, Read EXI, Carrasquillo JA, Carter CS, Yang JC, Fisher B, Aebersold P, Packard 
BS, Yu MY, and Rosenberg SA. In uiuo distribution of adoptively transferred lndium-111- 
labeled tumor infiltrating lympyhocytes and peripheral blood lymphocytes in patients with 
metastatic melanoma. J iVotl Cancer /nst 8 1 : 1 705- 1 7 1 7, 1989. 
32. Konrad MW, Hemstreet G, Hersh EM, Mansell PWA, Mertelsmann R, Kolltz JE, and Bradley 
EX3. Pharmacokinetics of recombinant interleukin 2 in humans. Cancer Res 50:2009-2017. 
1990. 
33. Culver KW. Morgan RA Osborne WRA et al. In vivo expression and survival of gene-modified 
T lymphocytes in rhesus monkeys. Human Gene Therapy 1:399-410, 1990. 
34. Culver K, Cometta K, Morgan R, et al. Lymphocytes as cellular vehicles for gene therapy in 
mouse and man. Proc Natl AccudSci, 88:3\55-3\59, 1991. 
[476] 
Recombinant DNA Research, Volume 19 
