FF 
Principal Investigator/Program Director (Last, first, middle): _ 
BIOGRAPHICAL SKETCH 
Give the following information tor the key personnel and consultants and collaborators Begin with the principal 
investigator/program director. Photocopy this page for each person. 
NAME 
BRENNER, Malcolm Keith 
POSITION TITLE 
Member, Hematology/Oncology 
EDUCATION (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) 
INSTITUTION AND LOCATION 
DEGREE 
YEAR 
CONFERRED 
FIELD OF STUDY 
Membership, Royal College of Physicians 
MRCP 
1977 
Medicine 
University of Cambridge 
PhD 
1981 
Immunology 
Membership, Royal College of Pathologists 
MRCPath 
1988 
Haematology 
Fellowship, Royal College of Physicians 
FRCP 
1990 
Medicine 
RESEARCH AND PROFESSIONAL EXPERIENCE: Concluding with present position, list, in chronological order, previous employment, experience, and 
honors Key personnel include the principal investigator and any other individuals who participate in the scientific development or execution of the project. 
Key personnel typically will include all individuals with doctoral or other professional degrees, but in some projects will include individuals at the masters or 
baccalaureate level provided they contribute in a substantive way to the scientific development or execution of the project. Include present membership on 
any Federal Government public advisory committee. List, in chronological order, the titles, all authors, and complete references to all publications during the 
past three years and to representative earlier publications pertinent to this application. DO NOT EXCEED TWO PAGES. 
1975 
1976 
1977 
1977-78 
1978-81 
1981-83 
1983-85 
1985-89 
1990 to 
present 
1990 to 
present 
House Physician to Professor M.D. Milne, Westminster Hospital, London, U.K. 
Senior House Officer to Professor J.P. Shillingford, Hammersmith Hospital, and Royal 
Postgraduate Medical School, London 
Senior House Officer to Professor M. Turner Warwick and Dr. P. Cole, Brompton 
Hospital, London 
Medical Registrar to Professor A.F. Lant and Dr. L.W. Loughridge, Westminster 
Hospital, London, U.K. 
Medical Research Council Training (MRC) Fellow, Division of Immunology, 
Department of Pathology, Cambridge University, U.K. 
MRC Clinical Scientist, Honorary Senior Registrar, Northwick Park Hospital, and 
Clinical Research Centre, London 
Lecturer in Haematology, Royal Free Hospital and Hospital for Sick Children, Great 
Ormond Street, London 
Senior Lecturer, Honorary Consultant Haematologist (Deputy Director, BMT Program) 
Royal Free Hospital, London, U.K. 
Professor, Departments of Pediatrics and Medicine, University of Tennessee, 
Memphis, Tennessee 
Member, Hematology/Oncology, and Director, Bone Marrow Transplant Program, St. 
Jude Children's Research Hospital, Memphis, Tennessee 
k 
SELECTED PUBLICATIONS (of 137 total) 
Heslop HE, Gottlieb DJ, Bianchi ACM, Meager A, Prentice HG, Mehta AB, Hoffbrand AV, 
Brenner MK. In vivo induction of gamma interferon and tumor necrosis factor by 
interleukin-2 infusion following intensive chemotherapy or autologous marrow 
transplantation. Blood 74:1374-1380, 1989. 
Gottlieb DJ, Prentice HG, Heslop HE, Bello-Fernandez C, Bianchi AC, Galazka AR, Brenner MK. 
Effects of recombinant interleukin-2 administration on cytotoxic function following high- 
dose chemo-radiotherapy for hematological malignancy. Blood 74:2335-2342, 1989. 
Duncombe AS, Heslop HE, Turner M, Meager A, Priest R, Exiey T, Brenner MK. Tumor necrosis 
factor mediates autocrine growth inhibition in a chronic leukemia. J Immunol 
143:3828-3834, 1989. 
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Recombinant DNA Research, Volume 19 
