Other possible autoimmune reactions may include skin rashes and joint inflammation. These reactions 
will be treated with appropriate medications. 
4. The research methods employed in this study utilize a virus to infect and transfer the interleukin-2 
gene into the cells. No side-effects have been observed in limited human studies with this procedure. 
There are, however, some theoretical risks associated with these methods. While the virus utilized to 
transfer genes into my cells has been modified to prevent its ability to proliferate and infect other cells, it 
is theoretically possible for the virus to become infectious. Infectious viruses of this type have produced 
cancer in animals. A blood test will be performed to determine whether an infectious virus has been 
generated. If an infectious virus is detected, I agree to be isolated in a hospital room or my home until the 
virus disappears from my blood to minimize the risks of infecting other individuals. 
5. The genetically modified cells will also contain a gene that produces a protein that inactivates 
certain antibiotics. These antibiotics are not commonly used in the treatment of human infections. In 
addition, as many other more commonly used antibiotics are not inactivated by this substance, the 
procedure is not expected to affect the therapy of bacterial infections that may occur during the course of 
my illness. 
6. There may be some pain, bleeding, bruising or infection at the blood withdrawal sites in my arms. 
These potential complications are rarely severe. 
Benefits Of The Study 
There may be no direct benefit to me from this therapy. It is possible that these treatments may enhance 
my body's immune response to my cancer. However, even if this occurs, this may have no beneficial 
effect on the course of my illness. However, from my participation in this study, the investigators may 
learn more about the role of the body's immune responses against cancer and about the use of gene 
transfer methods. This information may prove useful in the therapy of cancer patients in the future. 
Request for Autopsy 
I have been informed that important information may be obtained from an autopsy in the event of my 
death at any time in the future. I give my permission for this evaluation. 
Alternative Methods of Treatment 
I understand that alternative experimental treatments may also be available or that I may be treated by 
supportive care only without experimental therapy. 
Emergency, Side Effects, Illness or Questions About The Study 
If I need medical treatment for any reason, I must contact my regular cancer physician or the study 
physician at the following telephone numbers: 
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Recombinant DNA Research, Volume 19 
