TABLE OF CONTENTS 
I. INTRODUCTION AND BACKGROUND 3 
2 . OBJECTIVES 6 
3. PROTOCOL SCHEMA 7 
4. DESIGN OF CLINICAL PROCEDURES 8 
5. PATIENT SELECTION 11 
6. LOCATION 12 
7. PATIENT EVALUATION 12 
8. CRITERIA FOR RESPONSE 13 
9. REPORTING OF ADVERSE REACTIONS 14 
10. POTENTIAL RISKS OF RETROVIRAL-MEDIATED GENE TRANSFER 14 
II. STATISTICAL CONSIDERATIONS 16 
12. ETHICAL CONSIDERATIONS 16 
13. RESPONSIBILITIES 16 
14. RISKS AND BENEFITS 17 
15. COST AND PAYMENTS 17 
16. TREATMENT SCHEMA 17 
17. REFERENCES 18 
Recombinant DNA Research, Volume 19 
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