FF 
Pnncicxal Investioator/Program Director (Last, first, middle) 
BIOGRAPHICAL SKETCH 
Give the toliowiog irTlormation tor the Key (sersonnel arx3 consultants and coUatxjrators Begin with the pnnapal 
investigator/pfogram oireaor. Photocopy this page lor each person. 
lAME 
Michael T. Lotze, M.D. 
POSITION TITLE Professor of Surgery, Molecular 
Genetics and Biochemistry, Associate Director, 
Pittsburgh Cancer Institute/Surgical Oncology 
EDUCATION (begin wnn oaccaiaureate or other initial prolessicnai education, such as nursing, and include postdoaorai training.) 
INSTITUTION AND LOCATION 
DEGREE 
YEAR 
CONFERRED 
FIELD OF STUDY 
N.U. Honors Program in Medical 
Education, Evanston, IL 
B. Med. Sci 
1973 
Premedical Studies 
Northwestern Medical School, Chicago, IL 
M.D. 
1974 
Medicine 
RESEARCH AND PROFESSIONAL EXPERIENCE; Concluding with present position, list, in chronological order, previous employment, expenence. and 
honors. Key personnel include the prinapal investigator and any other individuals who participate in the scientific development or execution of the project. 
Key personnel typically will include all individuals wtth doctoral or other professional degrees, but in some projects will indude individuals at the masters or 
baccalaureate level provided they comribute m a substantive way to the scientific development or execution of the projea. Indude present membership on 
any Federal Government public advisory committee. List, in chronological order, the titles, all authors, and complete references to all publications during the 
three years and to representative earlier publicatiorts pertineni to this application. DO NOT EXCEED TWO PAGES, ct/w 
P ositions 
1975 Jr. Medical Fellow in Surgery, M.D. Anderson Tumor Institute, Houston, TX 
1975-1982 Intem/Resident in Surgery, Strong Memorial Hospital, Rochester, NY 
1977- 1978 Medical Officer, National Health Service Corps, Onamia, MN 
1978- 1980 Staff Fellow, Surgery Branch, National Cancer Institute, Bethesda, MD 
1982-1990 Senior Investigator, Surgery Branch, National Cancer Institute, Bethesda, MD 
1990-Pres. Director, Division of Surgical Oncology, Department of Surgery and A.ssociate 
Director, Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA 
Awards and Honors: 
1971-1974 
1982 
1986 
1987 
1988 
1990, 1993 
1990 
1991 
1991 
1992 
Activities 
1988-1990 
1990 
1990 
1991 
1992-1995 
Honors Program in Medical Education, Northwestern University 
Robert H. White Award for Excellence in Teaching, University of Rochester 
4th Ajinual Edith Hamilton Cancer Lecturer, Rochester, New York 
Special Achievement Award, DHHS, NIH 
4th Vender Lecturer, Northwestern University, Evanston, Illinois 
Coorg. Keystone Symposium on Cellular Immunity and the Immunotherapy of Cancer. Park Cits. L T. Taos NM 
Virginia Mason Research Center Distinquished Lecturer, Seattle, WA 
Annual John Palmer Lecturer, University of Toronto; Toronto, Ontario 
Tenth Hinshaw Lecturer, University of Rochester, Rochester, NY 
Coorganizer Keystone Symposium on Melanoma and Biology of the Neural Crest. Taos. NM 
Surgery Br. Rep., NCI Investigational Review Board 
Ad Hoc Reviewer, Experimental Immunology Study Section, NIH 
Chairman, Special Study Section, Experimental Immunology, NIH 
SSO/Program Committee/Research and Government Relations Committee 
ASCO/Young Investigator Award, Clinical Development Award Committee 
Editorial Boards: 
1988 - 1992 European Cytokine Journal; Journal of Immunotherapy (Assoc. Editor); Journal of Immunology, 
Contemporary Oncology, Melanoma Research 
Publications (out of 195) 
1 . 
2 . 
3. 
5. 
Lotze, M.T., Strausser, J.L., Rosenberg, SjA.; In vitro growth of cytotoxic human lymphocytes. II. Use of T cell 
growth factor (TCGF) to clone human T cells. J. Immunol. 124:2972-2978, 1980. 
Kawakami, Y., Custer, M.C., Rosenberg, SA., Lotze, M.T.; lnterIeukin-4 regulates lnterleukin-2 induction of 
lymphokine activated killer activity from human lymphocytes. J. Immunology . 142:3452-3461, 1989. 
Kawakami, Y., Rosenberg, SA., Lotze, M.T.; IL-4 promotes the growth of tumor infiltrating lymphocytes 
specific for human autologous melanoma. J. Exp. Med .. 168:2183-2191, 1988. 
Custer, M.C., Lotze, M.T.: A biologic assay specific for lL-4: Rapid Fluorescence Aissay for IL-4 detection in 
supernatants and serum. J Imm. Methods 128: 109-17, 1990. 
Kasid, A., Morecki, S., Lotze, M.T., et al.: Human Gene Transfer: Characterization of human tumor infiltrating 
lymphocytes as vehicles for retroviral mediated gene transfer in man. Pro. Nat. Acad. Sci.. 87:473-477. 1990. 
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Recombinant DNA Research, Volume 19 
