Federal Register / Vol. 59, No. 127 / Tuesday, July 5, 1994 / Notices 
34517 
organisms nor their gametes can escape 
into the supply or discharge system of 
the rearing container (e g., tank, 
aquarium, etc.) Acceptable barriers 
include appropriate filtration, 
irradiation, heat treatment, chemical 
treatment, etc. Moreover, the top of the 
rearing container shall be covered to 
avoid escape of the organism and its 
gametes. In the event of tank rupture, 
leakage, or overflow, the construction of 
the room containing these tanks should 
prevent the organisms and gametes from 
entering the building’s drains before the 
organism and its gametes have been 
inactivated. 
Other types of non-laboratory animals 
(e g., nematodes, arthropods, and certain 
forms of smaller animals) may be 
accommodated by using the appropriate 
BLl through BL4 or BLl-P through 
BL4-P containment practices and 
procedures as specified in Appendices 
G and P. 
OMB's “Mandatory Information 
Requirements for Federal Assistance 
Program Announcements" (45 FR 
39592) requires a statement concerning 
the official government programs 
contained in the Catalog of Federal 
Domestic Assistance. Normally NIH lists 
in its announcements the number and 
title of afiected individual programs for 
the guidance of the public. Because the 
guidance in this notice covers not only 
virtually every NIH program but also 
essentially every Federal research 
program in which DNA recombinant 
molecule techniques could be used, it 
has been determined to be not cost 
effective or in the public interest to 
attempt to list these programs. Such a 
list would likely require several 
additional pages. In addition, NIH could 
not be certain that every Federal 
program would be included as many 
Federal agencies, as well as private 
organizations, both national and 
international, have elected to follow the 
NIH Guidelines. In lieu of the 
individual program listing, NIH invites 
readers to direct questions to the 
information address above about 
whether individual programs listed in 
the Catalog of Federal Domestic 
Assistance are affected. 
Effective Date; June 24, 1994. 
Harold Varnius, 
Director, National Institutes of Health. 
[FR Doc. 94-16200 Filed 7-1-94; 8:45 am) 
BILLINC CODE 414O-0t-P 
(748J 
Recombinant DNA Research, Volume 19 
