* * * TABLE OF CONTENTS * * * 
I. Call to Order/Dr. Walters 7 
II. Chair Report on Minor Modifications to NIH-Approved Human Gene 
Transfer Protocols/Dr. Walters 8 
IE. Chair Report on Accelerated Review of Human Gene Transfer 
Protocols/Dr. Walters 8 
IV. Minutes of the June 9-10, 1994, Meeting 8 
V. Data Management Update/Dr. Smith 8 
VI. Discussion Regarding Criteria for RAC Review and Approval of Human 
Gene Transfer Protocols/Dr. Varmus 10 
Vn. Addition to Appendix D of the NIH Guidelines Regarding a Human 
Gene Transfer Protocol Entitled: A Phase I Study of an Adeno- 
Associated Virus-CFTR Gene Vector in Adult CF Patients with Mild 
Lung Disease /Dr. Flotte 15 
Vm. Addition to Appendix D of the NIH Guidelines Regarding a Human 
Gene Transfer Protocol Entitled: Gene Therapy for the Treatment 
of Metastatic Breast Cancer by In Vivo Infection with Breast-Targeted 
Retroviral Vectors Expressing Antisense C-Fos or Antisense C-Myc 
RNA/Dts. Holt and Arteaga 21 
IX. Addition to Appendix D of the NIH Guidelines Regarding a Human 
Gene Transfer Protocol Entitled: Evaluation of Repeat Administration 
of a Replication Deficient, Recombinant Adenovirus Containing the Normal 
Cystic Fibrosis Transmembrane Conductance Regulator cDNA to the 
Airways of Individuals with Cystic Fibrosis /Di. Crystal 27 
X. Amendments to Sections I, III, IV, V, and Appendix M of the NIH 
Guidelines Regarding NIH and FDA Consolidated Review of Human 
Gene Transfer Protocols/Drs. Wivel and Noguchi 34 
XI. Addition to Appendix D of the NIH Guidelines Regarding a Human 
Gene Transfer Protocol Entitled: A Pilot Study of Autologous 
Human Interleukin-2 Gene Modified Tumor Cells in Patients with 
Refractory or Recurrent Metastatic Breast Cancer /Dr. Lyerly 39 
XII. Chair Remarks 42 
Recombinant DNA Research, Volume 20 
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