Attachment II - Fbge 6 
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^ 9309-053* 
(T) Deisseroth, Albert B.; Kavanagh, John; and Champlin, Richard; University of Texas MD Anderson Cancer 
Center, Houston, Texas; Use of Safety-Modified Retroviruses to Introduce Chemotherapy Resistance 
Sequences into Normal Hematopoietic Cells for Chemoprotection During the Therapy of Ovarian Cancer A 
Pilot Trial. 
RAC Approval: 6-7-93/N1H Approval: 12-2-93 
Minor Modification: 2-25-94 
Minor Modification: 2-25-94 
(T) Nabel, Gary J.; University of Michigan Medical Center, Ann Arbor, Michigan; Immunotherapy for Cancer 
by Direct Gene Transfer into Tumors. 
RAC Approval: 6-7-93/NIH Approval: 9-3-93 
(T) Barranger, John A.; University of Pittsburgh, Pittsburgh, Pennsylvania, Gene Therapy for Gaucher Disease: 
Ex Vivo Gene Transfer and Autologous Transplantation of CD34( + ) Cells. 
RAC Approval: 6-7-93/NIH Approval: 9-3-93 
(T) Karlsson, Stefan and Dunbar, Cynthia; National Institutes of Health, Bethesda, Maryland, and Kohn, 
Donald B.; Childrens Hospital Los Angeles, Los Angeles, California; Retroviral Mediated Transfer of the 
cDNA for Human Glucocerebrosidase into Hematopoietic Stem Cells of Patients with Gaucher Disease. 
RAC Approval: 6-7-93/NIH Approval: 9-3-93 
(T) Galpin, Jeffrey E.; University of Southern California, Casciato, Dennis A.; Shared Medical Research 
Foundation, Tarzana, California, and Merchant, Bruce; Viagene, Inc., San Diego, California; A Preliminary 
Study to Evaluate the Safety and Biobgic Effects of Murine Retroviral Vector Encoding HIV-1 Genes [ HIV - 
IT(V)] in Asymptomatic Subjects Infected with HIV-1. 
RAC Approval: 6-7-93/NIH Approval: 9-3-93 
Minor Modification: 7-11-94 
(T) Nabel, Gary J.; University of Michigan Medical Center, Ann Arbor, Michigan; A Molecular Genetic 
Intervention for AIDS - Effects of a Transdominant Negative Form of Rev. 
RAC Approval: 6-7-93/NIH Approval: 9-3-93 
(T) Sobol, Robert and Royston, Ivor; San Diego Regional Cancer Center, San Diego, California; 
CONFIDENTIAL. 
NIH Approval: 12-28-92 
Major Amendment (Expedited Review)/NIH Approval: 5-11-93 
CLOSED: 10-20-93 (Patient death) 
(T) Raffel, Corey, Childrens Hospital Los Angeles, Los Angeles, California, and Culver, Kenneth; Iowa 
Methodist Medical Center, Des Moines, Iowa; Gene Therapy for the Treatment of Recurrent Pediatric 
Malignant Astrocytomas with In Vivo Tumor Transduction with the Herpes Simplex Thymidine Kinase Gene. 
RAC Approval: 6-8-93/NIH Approval 9-3-93 
(T) Hesdorffer, Charles and Antman, Karen; Columbia University College of Physicians and Surgeons, New 
York, New York; Human MDR Gene Transfer in Patients with Advanced Cancer. 
RAC Approval: 6-8-93/NIH Approval: 9-3-93 
(T) Ilan, Joseph; Case Western Reserve University School of Medicine and University Hospitals of Cleveland, 
Cleveland, Ohio; Gene Therapy for Human Brain Tumors Using Episome-Based Antisense cDNA 
Transcription of Insulin-Like Growth Factor I. 
RAC Approval: 6-8-93/NIH Approval: 12-2-93 
(T) Cassileth, Peter; Podack, Eckhard R.; Sridhar, Kasi; University of Miami, and Savaraj, Niramol; Miami 
Veterans Administration Hospital, Miami, Florida; Phase I Study of Transfected Cancer Cells Expressing the 
InterleuJdn-2 Gene Product in Limited Stage Small Cell Lung Cancer. 
RAC Approval: 9-9-93/NIH Approval: 12-2-93 
Minor Modification: 3-23-94 
Recombinant DNA Research, Volume 20 
[97] 
