Atta±mait II - F^e 9 
Deisseroth, Albert; Hortobagyi, Gabriel; Champlin, Richard; and Holmes, Frankie; MD Anderson Cancer 
Center, Houston, Texas; Use of Safety-Modified Retroviruses to Introduce Chemotherapy Resistance 
Sequences into Normal Hematopoietic Cells for Chemoprotection During the Therapy of Breast Cancer A 
Pilot Trial. 
RAC Approval: 6-9-94/NIH Approval: 7-12-94 
Liu, Johnson, M. and Young, Neal S.; National Institutes of Health, Bethesda, Maryland; Retroviral 
Mediated Gene Transfer of the Fanconi Anemia Complementation Group C Gene to Hematopoietic 
Progenitors of Group C Patients. 
RAC Approval: 6-9-99/NIH Approval: 2-12-94 
Roth, Jack A.; MD Anderson Cancer Center. Houston. Texas: Clinical Protocol for Modification of Tumor 
Suppressor Gene Expression and Induction of Apoptosis in Non-Small Cell Lune Cancer ( NSCLC ) with an 
Adenovirus Vector Expressing Wildtype p53 and Cisplatin. 
RAC Approval: 6-10-94/NIH Approval: Pending 
Sobol, Robert and Royston, Ivor; San Diego Regional Cancer Center; San Diego, California; Injection of 
Glioblastoma Patients with Tumor Cells Genetically Modified to Secrete Interleukin-2 (IL-2): A Phase I 
Study. 
RAC Approval: 6-10-94/NIH Approval: 7-12-94 
Lotze, Michael T; University of Pittsburgh. Pittsburgh. Pennsylvania; IL-12 Gene Therapy Using Direct 
Injection of Tumor with Genetically Engineered Autologous Fibroblasts. 
RAC Approval: 6-10-94/NIH Approval: Pending 
Simons, Jonathan; Johns Hopkins Oncology Center; Baltimore, Maryland; Phase I/II Study of Autologous 
Human GM-CSF Gene Transduced Prostate Cancer Vaccines in Patients with Metastatic Prostate Carcinoma. 
NIH/ORDA Approval: 8-3-94 
LEGEND: 
M = Human Gene Marking Protocol 
T = Human Gene Therapy Protocol 
* = Minor Modificalion(s) 
= Major Amendment(s) 
= RAC Approved/NIH Approval Pending 
September 2, 1994 
T 
M 
Total (T + M) 
| RAC APPROVED 
57 
24 
81 
j NIH APPROVED 
48 
24 
72 
9406-077 (T) 
9406-078 (T) 
9406-079 (T) 
9406-080 (T) 
9406-081 (T) 
9408-082 (T) 
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Recombinant DNA Research, Volume 20 
