GG 
Principal Investigator /Program Director (Last, first, rriddle): Holt, Jeffrey T. 
BIOGRAPHICAL SKETCH 
Give the following Information for the key personnel and consultants and collaborators. Begin with the principal 
investigator/program director. Photocopy this page for each person. 
CVs 
NAME 
POSITION TITLE 
Jeffrey T. Holt 
Associate Professor 
INSTITUTION AND LOCATION 
DEGREE 
YEAR 
CONFERRED 
F1ELDOFSTUDY 
Kalamzoo College 
University of Michigan School of Medicine 
B.A. 
M.D. 
1976 
1979 
Chemistry 
RESEARCH AND/OR PROFESSIONAL EXPERIENCE: Concluding with present position, list In chronological order previous employment, experience, and 
honors. Key personnel include the principal Investigator and any other individuals who participate in the scientific development or execution of the project. Key 
personnel typically will include all individuals with doctoral or other professional degrees, but in some projects will include individuals at the masters or 
baccalaureate level provided they contribute in a substantive way to the scientific development or execution of the project Include present membership on any 
Federal Government public advisory committee. List, in chronological order, the titles, all authors, and complete references to all publications during the past 
three years and to representative earlier publications pertinent to this application. DO NOT EXCEED TWO PAGES. 
1979-83 Resident, Department of Pathology, University of Rochester School of 
Medicine, Rochester, NY 
1983 
Diplomate, American Board of Pathology (AP/CP) 
Research Associate, Clinical Hematology Branch, National Heart Lung 
and Blood Institute, NIH, Bethesda, MD 
Assistant Professor, Departments of Cell Biology and Pathology 
Vanderbilt University School of Medicine 
Associate Professor, Departments of Cell Biology and Pathology 
Vanderbilt University School of Medicine 
Molecular Biology Study Section (Ad hoc) 
Cellular Physiology Study Section (Ad hoc) 
Experimental Hematology (Ad hoc) 
SELECTED PUBLICATIONS (from 46 publications excluding abstracts) 
Holt, J.T., T.V. Gopal, A.D. Moulton, and A.W. Nienhuis. Inducible production of c-fos antisense RNA 
inhibits 3T3 cell proliferation. Proc. Natl. Acad. Sci. USA, 83:4793-4797, 1986. 
Kerr, L., J.T. Holt, and L.M. Matrisian. Regulation of transin transcription by c-fos dependent and 
independent pathways. Science, 242:1424-1427, 1988. 
Pietenpol, J.A., J.T. Holt, R.W. Stein, and H.L. Moses. TGF-betal suppression of c- myc gene 
transcription inhibits keratinocyte proliferation. Proc. Natl. Acad. Sci. USA, 87:3758-3762, 1990. 
1983-1987 
1987-1991 
1991- 
6/91 
2/92 
6/93 
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